2012 Fiscal Year Final Research Report
Anti-tumor action by PPARgamma ligands in pancreatic cancer: analysis of angigenesis-related genes expression
| Project/Area Number |
22590753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOZU Tsukasa 旭川医科大学, 医学部, 准教授 (30312367)
KUMEI Shima 旭川医科大学, 大学病院, 医員 (00548969)
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| Project Period (FY) |
2010 – 2012
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| Keywords | PPARgamma / cancer / VEGF |
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| Research Abstract |
We have demonstrated that human cancer cell lines (PC-14 and RERF) express PPARgamma. Troglitazone, a PPARgamma ligand, dose-dependently inhibited cell growth, and upregulated mRNA and protein expression of VEGF. A inhibitor of VEGF significantly blocked the troglitazone-induced inhibition of cell growth, suggesting that VEGF may play a vital role in the inhibition of cell growth by troglitazone in human cance cells.
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