2012 Fiscal Year Final Research Report
Evaluation of efficacy and safety of gene-chemotherapy for biliary cancers using oncolytic adenovirus armed with UPRT
| Project/Area Number |
22590755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ABEI Masato 筑波大学, 医学医療系, 准教授 (20261802)
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| Co-Investigator(Kenkyū-buntansha) |
HYODO Ichinosuke 筑波大学, 医学医療系, 教授 (60416469)
FUKUDA Kuniaki 筑波大学, 医学医療系, 講師 (50447257)
HAMADA Hirofumi 東京薬科大学, 生命科学部, 教授 (00189614)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腫瘍融解ウイルス / 遺伝子治療 / アデノウイルス / サイクロフォスファマイド |
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| Research Abstract |
Oncolytic viruses offer great promise as cancer therapeutics, but host antiviral immunity must be overcome for their efficacy. In this study, we demonstrated the efficacy and safety of an oncolytic adenovirus (OAd) expressing uracil phosphoribosyltransferase (UPRT), which greatly enhances the sensitivity of cancer cells to 5-fluorouracil, and further enhancement of this efficacy by a high-dose or clinically-approved safe dose of the immunosuppressive agent cyclophosphamide (CP) in Syrian hamsters with or without preexisting immunity. This is the first study demonstrating enhancement by CP of the efficacy of an OAd armed with a therapeutic gene in Ad-permissive immunocompetent animals, indicating the ability of CP to overcome the hurdle of antiviral immunity for effective virus-gene therapy.
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Research Products
(12 results)
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[Journal Article] Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters2013
Author(s)
Hasegawa N, Abei M, Yokoyama KK, Fukuda K, Seo E, Kawashima R, Nakano Y, Yamada T, Nakade K, Hamada H, Obata Y, Hyodo I
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Journal Title
Int. J.Cancer
Volume: PMID: 23444104(印刷中)
DOI
Peer Reviewed
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[Journal Article] EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus2011
Author(s)
Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK
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Journal Title
Int. J. Cancer
Volume: 129巻
Pages: 1244-1253
Peer Reviewed
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[Presentation] Immunosuppression enhances the Efficacy of oncolytic adenovirus-mediated uracil phosphoribosyl Transferase (UPRT)/ 5-fluorouracil suicide gene therapy in immunocompetent adenoviruspermissive Syrian hamsters2012
Author(s)
Hasegawa N, Abei M, Fukuda K,Seo E,Wakayama M, Kawashima R, Hamada H, Yokoyama KK, Obata Y, Hyodo I
Organizer
2012国際癌遺伝子・細胞治療学会(ISCGT)
Place of Presentation
フラマホテル,シンガポール
Year and Date
2012-10-04
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[Presentation] Efficacy and safety of oncolytic adenovirus combined with UPRT/5-FU suicide gene system: Evaluation in syngenic pancreas cancer model in immunocompetent,adenovirus-permissive Syrian hamsters.2012
Author(s)
Hasegawa N, Abei M, Fukuda K,Kawashima R,Seo E, WakayamaM, Hamada H, Yokoyama KK, Obata Y, Hyodo I
Organizer
第18回日本遺伝子治療学会総会
Place of Presentation
熊本テルサ,熊本
Year and Date
2012-06-29
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[Presentation] Efficacy and safety of gene-chemo therapy using oncolytic adenovirus expressing uracil phosphoribosyl transferase (UPRT) followed by 5-fluorouracil administration in syngenic pancreatic and biliary cancers in immunocompetent adenoviruspermissive Syrian ha2012
Author(s)
Hasegawa N, Abei M, Fukuda K,SeoE, Wakayama M, KawashimaR, Murata T, Hamada H, YokoyamaKK, Obata Y, Hyodo I.
Organizer
第15回米国遺伝子・細胞治療学会
Place of Presentation
ペンシルベニア・コンベンションセンター,フィラデルフィア,アメリカ合衆国
Year and Date
2012-05-17
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