2012 Fiscal Year Final Research Report
Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cells
| Project/Area Number |
22590759
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MURAI Noriyuki 東京慈恵会医科大学, 医学部, 講師 (60300927)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アンチザイム / ポリアミン / がん / c-Myc / 低酸素 |
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| Research Abstract |
c-mycis known as the most famous oncogene and encodes c-MYC oncoprotein. c-MYC contributes to cell proliferation, ribosomal biosynthesis, glycolysis and apoptosis. It has been reported that regulation of c-MYC degradation is mediated by ubiquitin-proteasome pathway. However wefound that antizyme 2 protein which regulates cellular polyamine level accelerates degradation of c-MYC by the proteasome ubiquitin-independently. In this study, weshowed that novel ubiquitin independent c-MYC degradation pathway exist in the cells.
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