Challenging to the real-time in vivo diagnosis for inflammatory bowel disease by using super-magnifying endoscope.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590763
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: OGATA Haruhiko 慶應義塾大学, 医学部, 教授 (30177117)
• Co-Investigator(Kenkyū-buntansha): KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
• Project Period (FY): 2010 – 2012
• Keywords: 超拡大内視鏡 / 炎症性腸疾患 / 迅速病理診断 / 潰瘍性大腸炎 / リアルタイム

Research Abstract

We have established an Super-magnifying endoscopy score (Endocytoscopy system score: ECSS) to determine the histopathological activity index of Ulcerative colitis. ECSS of intestinal mucosa of UC, i.e., the shape of and distance between crypts, and micro

Research Products

• [Journal Article] Applicability of second generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study. (2013)
  • Author(s): Hosoe N, Matsuoka K, Naganuma M, Ida Y, Ishibashi Y, Kimura K, Yoneno K, Usui S, Kashiwagi K, Hisamatsu T, Inoue N, Kanai T, Imaeda H, Ogata H, Hibi T.
  • Journal Title: Gastroenterol Hepatol.
  • DOI: doi:10.1111/jgh.12203.
  • Peer Reviewed
• [Journal Article] Long-term prognosis of patients with ulcerative colitis treated with cytapheresis therapy. (2013)
  • Author(s): Takayama T, Kanai T, Matsuoka K, Okamoto S, Sujino T, Mikami Y, Hisamatsu T, Yajima T, Iwao Y, Ogata H, Hibi T
  • Journal Title: J Crohns Colitis Volume: 7(2) Pages: e49-54
  • Peer Reviewed
• [Journal Article] Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis. (2012)
  • Author(s): Ogata H, Kato J, Hirai F, Hida N, Matsui T, Matsumoto T, Koyanagi K, Hibi T
  • Journal Title: Inflamm Bowel Dis Volume: 18(5) Pages: 803-808
  • Peer Reviewed
• [Journal Article] The use of infliximab in the prevention of postsurgical recurrence in polysurgery Crohn's disease patients: a pilot open-labeled prospective study. (2012)
  • Author(s): Sakuraba A, Sato T, Matsukawa H, Okamoto S, Takaishi H, Ogata H, Iwao Y, Hibi T
  • Journal Title: Int J Colorectal Dis Volume: 27(7) Pages: 947-52
  • Peer Reviewed
• [Journal Article] Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease. (2011)
  • Author(s): Miyoshi J, Yajima T, Okamoto S, Matsuoka K, Inoue N, Hisamatsu T, Shimamura K, Nakazawa A, Kanai T, Ogata H, Iwao Y, Mukai M, Hibi T
  • Journal Title: J Gastroenterol Volume: 46(9) Pages: 1056-63
  • Peer Reviewed
• [Journal Article] Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis. (2011)
  • Author(s): Bessho R, Kanai T, Hosoe N, Kobayashi T, Takayama T, Inoue N, Mukai M, Ogata H, Hibi T.
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 1197-202
  • Peer Reviewed
• [Journal Article] Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells. (2011)
  • Author(s): Sujino T, Kanai T, Ono Y, Mikami Y, Hayashi A, Doi T, Matsuoka K, Hisamatsu T, Takaishi H, Ogata H, Yoshimura A, Littman DR, Hibi T
  • Journal Title: Gastroenterology. Volume: 141(3) Pages: 1014-23
  • Peer Reviewed
• [Journal Article] A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography. (2011)
  • Author(s): Hosoe N, Imaeda H, Okamoto S, Bessho R, Ida Y, Kobayashi S, Kanai T, Hibi T, Ogata H.
  • Journal Title: Gastrointest Endosc Volume: 74(3) Pages: 690-691
  • Peer Reviewed
• [Journal Article] Evaluation of small-intestinal abnormalities in adult patients with Henoch-Schonlein purpura using video capsule. (2011)
  • Author(s): Ichikawa R, Hosoe N, Imaeda H, Takabayashi K, Bessho R, Ida Y, Naganuma M, Hisamatsu T, Inoue N, Kanai T, Iwao Y, Mukai M, Hibi T, Ogata H.
  • Journal Title: Endoscopy Volume: 43(2) Pages: 162-163
  • Peer Reviewed
• [Journal Article] In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope. (2010)
  • Author(s): Hosoe N, Kobayashi T, Kanai T, Bessho R, Takayama T, Inoue N, Imaeda H, Iwao Y, Kobayashi S, Mukai M, Ogata H, Hibi T.
  • Journal Title: Gastrointest Endosc. Volume: 72(3) Pages: 643-646
  • Peer Reviewed
• [Presentation] Feasibility of Evaluating the Mucosal Inflammation in Ulcerative Colitis by Using a Second Generation Colon Capsule Endoscope. (2012)
  • Author(s): Hosoe N, Matsuoka K, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Usui S, Kashiwagi K, Hisamatsu T, Inoue N, Kanai T, Imaeda H, Hibi T, Ogata H
  • Organizer: Asian Pacific Digestive Week 2012
  • Place of Presentation: Bangkok
  • Year and Date: 20121205-08
• [Presentation] In vivo visualization and evaluation of colorectal inflammation in ulceretivecolitis by a newly integrated endocytoscopy. (2011)
  • Author(s): Kimura K, Kanai T, Bessho R, Hosoe N, Kobayashi T, Takayama T, Inoue N, Mukai M, Ogata H, and Hibi T
  • Organizer: Digestive Disease Week2011
  • Place of Presentation: Chicago
  • Year and Date: 20110507-10
• [Presentation] Analysis of Problems with Methodology for the Practical Use of Magnetically Guided Capsule Endoscopy. (2011)
  • Author(s): Hosoe N, Ogata H, Rey JF, Ohtsuka K, Ogata N, Ikeda K, Aihara H, Pangtay I, Hibi T, Kudo S, and Tajiri H
  • Organizer: Digestive Disease Week2011
  • Place of Presentation: Chicago
  • Year and Date: 20110507-10
• [Presentation] Real-time in vivo pathological diagnosis by using Endocytoscopy system. (2011)
  • Author(s): Ogata H.
  • Organizer: The 81th Annual Meeting of The JSGE
  • Place of Presentation: Nagoya
  • Year and Date: 2011-08-18
• [Presentation] 日比紀文:カプセル内視鏡による成人発症Henoch-Schoenlein 紫斑病の小腸病変の検討 (2011)
  • Author(s): 細江直樹、緒方晴彦
  • Organizer: 第97回日本消化器病学会総会 パネルディスカッション
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Real-time in vivo diagnosis of trophozoites in patients with amoebic colitis using newly developed endocytoscope. (2010)
  • Author(s): Hosoe N, Kobayashi T, Kanai T, Bessho R, Takayama T, Inoue N, Imaeda H, Ogata H, and Hibi T
  • Organizer: 18th United European Gastroenterology Week
  • Place of Presentation: Barcelona
  • Year and Date: 20101023-27
• [Presentation] Long-term prognosis of ulcerative colitis patients treated with cytoapheresis therapy (2010)
  • Author(s): Takayama T, Okamoto S, Naganuma M, Saito R, Sujino T, Mikami T, Inoue N, Hisamatsu T, Yajima T, Matsuoka K, Ogata H, Kanai T, Iwao Y and Hibi T
  • Organizer: 5th Japan-Korea IBD Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2010-10-02
• [Book] Crohn's Disease and Ulcerative Colitis. (Chapter 24. Endoscopic Assessment of Disease Activity and Mucosal Healing in Inflammatory Bowel Disease.) (2012)
  • Author(s): Haruhiko Ogata and Toshifumi Hibi
  • Total Pages: 754, 321-331
  • Publisher: Speinger