Establishment of the therapy of diastolic heart failure

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590766
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Jun 東北大学, 病院, 講師 (00375081)
• Co-Investigator(Kenkyū-buntansha): SHIMOKAWA Hiroaki 東北大学, 大学院・医学系研究科, 教授 (00235681)
• Project Period (FY): 2010 – 2012
• Keywords: 循環器 / 内科 / 臨床

Research Abstract

The purpose of this study was to determine the prognostic impact of nutritional status in patients with diastolic heart failure (DHF) using our prospective observational study named the CHART-2 (Chronic Heart failure Analysis and Registry in the Tohoku district-2). At the enrollment, their nutritional status was assessed by the CONUT score, a widely used nutritional status score representing the combined impact of serum albumin, total cholesterol level, and total lymphocyte count. After adjustment by sex, age, history of CAD, Cre, LVEF, anemia, and history of cancer, CONUTS〓5 was an independent prognostic marker in the patients with DHF. Undernutrition is an important predictor for cardiac death and a novel therapeutic target in patients with DHF.

Research Products

• [Journal Article] Plasma cyclophilin A is a novel biomarker for coronary artery disease (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Journal Title: Circ J Volume: 77 Pages: 447-455
• [Journal Article] Effect of the Great East Japan Earthquake Disaster on cardiovascular diseases - A report from the 10 hospitals in the Disaster area- (2013)
  • Author(s): Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T, Sukegawa H, Ogata K, Shimokawa H.
  • Journal Title: Circ J Volume: 77 Pages: 490-493
• [Journal Article] Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registry study of the Japanese Coronary Spasm Association- (2013)
  • Author(s): Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H.
  • Journal Title: Eur Heart J Volume: 34 Pages: 258-267
• [Journal Article] Enhanced Rho-kinase activity in patients with vasospastic angina after the Great EastJapan Earthquake. (2012)
  • Author(s): Nihei T, Takahashi J, Kikuchi Y, Takagi Y, Hao K, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
  • Journal Title: Circ J Volume: 76 Pages: 2892-2894
• [Journal Article] The Great East Japan Earthquake Disaster and cardiovascular diseases (2012)
  • Author(s): Aoki T, Fukumoto Y, Yasuda S, Sakata Y, Ito K, Takahashi J, Miyata S, Tsuji I, Shimokawa H.
  • Journal Title: Eur Heart J Volume: 33 Pages: 2796-2803
• [Journal Article] Involvement of Rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patientswith coronary artery disease (2012)
  • Author(s): Aizawa K, Yasuda S, Takahashi J, Takii T, Kikuchi Y, Tsuburaya R, Ito Y, Nakayama M, Takeda M, Shimokawa H.
  • Journal Title: Circ J Volume: 76 Pages: 2552-2560
• [Journal Article] Urbanization, life-style changes and incidence andin-hospital mortality from acute myocardial infarction in Japan - Report from the MIYAGI-AMI Registry- (2012)
  • Author(s): Hao K, Yasuda S, Takii T, Ito Y, Takahashi J, Ito K, Nakayama M, Shiba N, Fukumoto Y, Shimokawa H.
  • Journal Title: Circ J Volume: 76 Pages: 1136-1144
• [Journal Article] onbehalf of the CHART-2 Investigators. Urinary albumin excretion in heart failure with preserved ejection fraction - An interim analysis of the CHART-2 Study- (2012)
  • Author(s): Miura M, Shiba N, Nochioka K, TakadaT, Takahashi J, Kohno H, Shimokawa H
  • Journal Title: Eur J Heart Fail Volume: 14 Pages: 367-376
• [Journal Article] Long-term treatment with nifedipine suppresses coronary hyperconstrcting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: Possible involvement of Rho-kinase pathway- (2012)
  • Author(s): Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H.
  • Journal Title: Eur Heart J Volume: 33 Pages: 791-799
• [Journal Article] EnhancedRho-kinase activity in circulating neutrophils of patients with vasospastic angina -Possible biomarker for diagnosis and disease activity assessment- (2011)
  • Author(s): Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H.
  • Journal Title: J Am Coll Cardiol Volume: 58 Pages: 1231-1237
• [Journal Article] Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris (2010)
  • Author(s): Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, YasudaS, Kuriyama S, Tsuji I, Shimokawa H.
  • Journal Title: Circ J Volume: 74 Pages: 589-591
• [Journal Article] Trends in acute myocardial infarction and mortality over 30 years in Japan: Report from the MIYAGI-AMI Registry Study (2010)
  • Author(s): Takii T, Yasuda S, Takahashi J, Ito K, Shiba N, Shirato K, Shimokawa H.
  • Journal Title: Circ J Volume: 74 Pages: 93-100
• [Journal Article] Prognostic impact of blood ureanitrogen changes during hospitalization in patients with acute heart failure syndrome
  • Author(s): Miura M, Sakata Y, Nochioka K, Takahashi J, Takada T, Miyata S, Hiramoto T, Inoue K, Tamaki K, Shiba N, Shimokawa H.
  • Journal Title: Circ J Volume: (in press)
  • URL: http://dx.doi.org/10.1253/circj.CJ-12-1390
• [Journal Article] Gender differences in clinical characteristics and outcomes of patients with vasospastic angina -A report from the Japanese Coronary SpasmAssociation-
  • Author(s): Kawana A, Takahashi J, Takagi Y, Yasuda S, Sakata Y, Tsunoda R, Ogata Y,Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Kubo N, Momomura S, Ogawa H, Shimokawa H.
  • Journal Title: Circ J Volume: (in press)
  • URL: http://dx.doi.org/10.1253/circj.CJ-12-1486
• [Presentation] Beneficial Effects of a Single Prophylactic Hemodialysis on Renal Function Worsening after Percutaneous Coronary Intervention in Patients with Severe CKD. (2013)
  • Author(s): Tsuburaya R, Takahashi J, Itoh Y, Shirato T, Yasuharu Matsumoto , Kenta Ito , Masaharu Nakayama , Hiroaki Shimokawa
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Age-dependent differences in clinical characteristics and outcomes of female patients withvasospastic angina. (2013)
  • Author(s): Kawana A, TakahashiJ, Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Gotoh T, Tanabe Y, Sueda S, Kubo N, Momomura S, Ogawa H, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Characteristics of patients with acute myocardial infarction who did not receive primary PCI -A report from the Miyagi AMI Study- (2013)
  • Author(s): Hao K, TakahashiJ, Nihei T, Tsuburaya R, Shirato T, ItohY, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Improved emergency care of acute myocardial infarction during the Great East Japan Earthquake Disaster -The Miyagi AMI Registry Study- (2013)
  • Author(s): Hao K, Takahashi J, Nihei T, Tsuburaya R, Shirato T, Itoh Y, Matsumoto Y, Nakayama M, Kenta Ito,Yasuda S, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Chronic nitrate therapy in patients with vasospastic angina -Multicenter registry study of theJapanese Coronary Spasm Association- (2013)
  • Author(s): Takagi Y, Takahashi J, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Gotoh T, Tanabe Y, Ogawa H, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Circadian variationof Rho-kinase activity in patients with vasospastic angina. (2013)
  • Author(s): Nihei T, Takahashi J, Kikuchi Y, Hao K, Takagi Y, Tsuburaya R, Shirato T, Itoh Y, Matsumoto Y, Nakayama M, Ito K, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Nitrates as a concomitant therapy in patients with vasospastic angina -A report from the Japanese Coronary Spasm Association- (2013)
  • Author(s): (RT12: How to Manage Intractable Coronary Artery Spasm)Takagi Y, Takahashi J, Yasuda S, Ogata Y, Sumiyoshi T, Goto T, Ogawa H,Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] Prognostic impact of coronary revascularization therapy in patients with ischemic heart failure. (2013)
  • Author(s): (SY01: Progress in Coronary Revascularization: CABG andPCI for Severe Coronary Artery Disease) Takahashi J, Sakata Y, Nochioka K, Miura M, Takada T, Miyata S, Shimokawa H.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130315-17
• [Presentation] 急性心筋梗塞の院内死亡率の性差に関する因子の検討-宮城県心筋梗塞対策協議会からの報告- (2013)
  • Author(s): 伊藤愛剛、高橋潤、羽尾清貴、円谷隆治、白戸崇、松本泰治、二瓶太郎、中山雅晴、伊藤健太、安田聡、下川宏明
  • Organizer: 第6回日本性差医学・医療学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20130201-02
• [Presentation] 冠攣縮性狭心症患者における性別・年代別の臨床像と予後の違い (2013)
  • Author(s): 川名暁子、高橋潤、高木祐介、安田聡、角田隆輔、緒方康博、関敦、住吉徹哉、松井幹之、後藤敏和、田辺恭彦、末田章三、久保典史、百村伸一、小川久雄、下川宏明
  • Organizer: 第6回日本性差医学・医療学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20130201-02
• [Presentation] 急性心筋梗塞患者における冠動脈インターベンション未施行例の性差に関する検討-宮城県心筋梗塞対策協議会からの報告- (2013)
  • Author(s): 羽尾清貴、高橋潤、二瓶太郎、円谷隆治、白戸崇、伊藤愛剛、松本泰治、中山雅晴、伊藤健太、安田聡、下川宏明
  • Organizer: 第6回日本性差医学・医療学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20130201-02
• [Presentation] Acute heart failure caused by biventricular involvement of Takotsubo cardiomyopathy. (2012)
  • Author(s): Tsuburaya R, Takahashi J, Ito Y, Takagi Y, Matsumoto Y, Nakayama M, Ito K, Shimokawa H.
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20121130-1202
• [Presentation] Influence of coexisting heart failure on non-performance of primary percutaneous coronary intervention in patients with acutemyocardial infarction. (2012)
  • Author(s): Hao K, Takahashi J, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20121130-1202
• [Presentation] Cessasion of spironolactone worsens long-term prognosis of heartfailure patients. (2012)
  • Author(s): Nakayama M, Takahashi J, Ito K, Matsumoto Y, Ito Y, Tsuburaya R, Shiroto T, Takagi Y, Hao K, Shimokawa H.
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20121130-1202
• [Presentation] Beneficial effects of a single prophylactic hemodialysis onrenal function worsening after percutaneous coronary intervention in patients with severe CKD. (2012)
  • Author(s): Tsuburaya R, Takahashi J, Takagi Y, Ohhashi J, Itoh Y, Matsumoto Y, Takeda M, Nakayama M, Itoh K, Yasuda S, Shimokawa H.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] Prognostic impact of long-acting nitrate therapy in patients with vasospastic angina -a report from the Japanese Coronary Spasm Association-. (2012)
  • Author(s): Takagi Y, TakahashiJ, Nihei T, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Gotoh T,Tanbae Y, Ogawa H, Shimokawa H.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] Novel clinical risk score for prediction of cardiac events in VSA patients -a report from the Japanese Coronary Spasm Association-. (2012)
  • Author(s): Takagi Y, Takahashi J, Nihei T, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Gotoh T,Tanbae Y, Ogawa H, Shimokawa H.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] Clinical implications of coronary spasm provocation tests -multicenter registry study of the Japanese Coronary Spasm Association-. (2012)
  • Author(s): Takagi Y, Takahashi J, Nihei T, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Gotoh T,Tanbae Y, Ogawa H, Shimokawa H.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] Increased rho-kinase activity in patients with vasospastic angina after the East Japan EarthquakeDisaster. (2012)
  • Author(s): Nihei T, Takahashi J, Kikuchi Y, Itoh Y, Nakayama M, Tsuburaya R, Ohhashi J, Takagi Y, Itoh K, Yasuda S, Shimokawa H.
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] 冠攣縮性狭心症における性差:冠攣縮研究会における知見 (2012)
  • Author(s): 川名暁子、高橋潤、安田聡、高木祐介、角田康夫、緒方康博、関敦、住吉徹哉、松井幹之、後藤敏和、田辺恭彦、末田章三、久保典史、百村伸一、小川久雄、下川宏明
  • Organizer: 第5回日本性差医学・医療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20120204-05
• [Presentation] Increased incidence of heart failure in the Tohoku Earthquake - Initial report from the Tohoku University Hospital- (2011)
  • Author(s): Takahashi J, Yasuda S, nakayama M, Ito Y, Ito K, Fukuda K, Fukumoto Y, Shiba N, Shimokawa H.
  • Organizer: 第15回日本心不全学会
  • Place of Presentation: 鹿児島市
  • Year and Date: 20111013-15
• [Presentation] Optical Coherence Tomographyを用いた攣縮を生じる冠動脈の微細構造の解析:局所性冠攣縮とびまん性冠攣縮の差異. (2011)
  • Author(s): 武田守彦、高橋潤、伊藤健太、中山雅晴、安田聡、下川宏明
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20110923-25
• [Presentation] 心腎症候群を合併した心不全症例における持続腎代替療法の有用性. (2011)
  • Author(s): 高橋潤、安田聡、柴信行、下川宏明
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20110923-25
• [Presentation] Morphological analysis of the coronary arterial wall of patients withvasospastic angina pectoris with optical coherence tomography. (2011)
  • Author(s): Takeda M, Takahashi J, Nakayama M, Ito K, Yasuda S, Shimokawa H.
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20110803-04
• [Presentation] Continuous renal replacement therapy in patients with acute decompensated heart failure and cardio-renal syndrome. (2011)
  • Author(s): Takahashi J, YasudaS, Shiba N, Nakayama M, Shimokawa H.
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20110803-04
• [Presentation] 心腎症候群を合併した急性心不全症例における持続腎代替療法の検討. (2010)
  • Author(s): 高橋潤、安田聡、柴信行、中山雅晴、下川宏明
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100917-19
• [Presentation] 腹部大動脈瘤患者における術前冠動脈造影及び冠血行再建術の有用性. (2010)
  • Author(s): 武田守彦、高橋潤、伊藤健太、中山雅晴、安田聡、下川宏明
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100917-19
• [Presentation] Life-threatening complications after sirolimus-eluting stent implantation. (2010)
  • Author(s): Takeda M, Takahashi J, Ito K, Nakayama M, Yasuda S, Shimokawa H.
  • Organizer: 第19回日本心血管インターベンション 治療学会(CVIT2010)
  • Place of Presentation: 仙台
  • Year and Date: 20100822-24
• [Presentation] A hybrid strategy with percutaneous coil embolization and re-CABG for giantcoronary aneurysm in a patient undergoneDor procedure. (2010)
  • Author(s): Takahashi J, Yasuda S, Takeda M, Ito Y, Tsuburaya R, Takagi Y, Oda K, Kawamoto S, takase B, Tabayashi K, Shimokawa H.
  • Organizer: 第19回日本心血管インターベンション治療学会(CVIT2010)
  • Place of Presentation: 仙台
  • Year and Date: 20100822-24