2012 Fiscal Year Final Research Report
Effects of PPAR-gamma agonist on lipid contents in the heart and kidney and cardiac function in hypertension/diabetes animal models
| Project/Area Number |
22590770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Kan 東京大学, 医学部附属病院, 助教 (60422292)
TSUKAMOTO Kazuhisa 福島県立医科大学, 医学部, 教授 (20251233)
SEKI George 東京大学, 医学部附属病院, 講師 (30206619)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床心血管病態学 |
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| Research Abstract |
Effects of pioglitazone, a PPAR-γ agonist, in angiotensin II-infused rat were examined. Angiotensin II increased the serum levels and cardiac concentration of triglycerides, both of which were inhibited by pioglitazone. Cardiac function that was assessed by ex vivo Langendorff cardiac perfusion system showed that pioglitazone improved both systolic and diastolic cardiac function after transient global ischemia and reperfusion. Pioglitazone ameliorates histologic and functional cardiac damage induced by angiotensin II.
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Research Products
(8 results)
