• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Investigation on molecular mechanism for ischemic cardioprotective effect of endogenous GLP-1 and its clinical significance

Research Project

  • PDF
Project/Area Number 22590775
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionGifu University

Principal Investigator

HATTORI Arihiro  岐阜大学, 医学部附属病院, 助教 (20542418)

Co-Investigator(Kenkyū-buntansha) MINATOGUCHI Shinya  岐阜大学, 医学系研究科, 教授 (20190697)
Project Period (FY) 2010 – 2012
KeywordsGLP-1 / 心筋梗塞 / 左室機能障害
Research Abstract

In a rabbit model of myocardial infarction with 30 min coronary ischemia and 48 hours of reperfusion, we demonstrated that oral administration of α-glucosidase inhibitors voglibose and miglitol reduced the myocardial infarct size throughproduction of plasma GLP-1, activation of PI3 kinase-Akt-NO pathway and opening of mitochondrial KATP channels. In a clinical study, we demonstrated that plasma GLP- level was significantly increased in patients with impaired cardiac function as compared with those with preserved cardiac function, and that plasma GLP-1 level was inversely correlated with left ventricular ejection fraction. These results suggest that endogenous GLP-1 is a cardioprotective agent for ischemic heart disease and left ventricular dysfunction.

  • Research Products

    (5 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.2011

    • Author(s)
      Iwasa M, Yamada Y, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Shiraki T, Yamaki T, Ushikoshi H, Hattori A, Aoyama T, Nishigaki K, Takemura G., Fujiwara H, Minatoguchi S.
    • Journal Title

      Br J Pharmacol

      Volume: 164 Pages: 119-131

    • Peer Reviewed
  • [Journal Article] Anti-diabetic drug voglibose is protective against ischemia-reperfusion injury via GLP-1 receptors and PI3 kinase-Akt-eNOS pathway in rabbits.2010

    • Author(s)
      Iwasa M, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Yamada Y, Shiraki T, Yamaki T, Ushikoshi H, Aoyama T, Nishigaki K, Takemura G, Fujiwara H, Fujiwara T, Minatoguchi S.
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 55 Pages: 625-34

    • Peer Reviewed
  • [Journal Article] Elevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors in patients with left ventricular dysfunction.

    • Author(s)
      Hattori A, Kawamura I, Yamada Y, Kanamori H, Aoyama T, Ushikoshi H, Kawasaki M, Nishigaki K, Takemura G, Minatoguchi S.
    • Journal Title

      BMJ Open

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Increased Level of Plasma GLP-1 in Patients with Left Ventricular Dysfunction may serve as a Compensatory Mechanism for Cardiac Function.2012

    • Author(s)
      Hattori A, Kawamura I, Yamada Y, Kanamori H, Aoyama T, Kawasaki M, Nishigaki K, Takemura G, Minatoguchi S.
    • Organizer
      AHA2012
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      20121103-07
  • [Presentation] Plasma GLP-1 (Glucagon-Like Peptide 1) Level may be Essential Part in Patients with Left Ventricular Dysfunction.2012

    • Author(s)
      服部有博
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-16

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi