2012 Fiscal Year Final Research Report
Individualized indication for Cardiac resynchronization therapy
| Project/Area Number |
22590778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
INDEN Yasuya 名古屋大学, 医学部附属病院, 講師 (10359747)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心不全 / 心臓再同期療法 / 心エコー |
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| Research Abstract |
An echocardiographic index named i-Index for predicting responses to cardiac resynchronization therapy (CRT) is a newly-devised one in the post- PROSPECT study era. Receiver-operating characteristics curve analyses wereused to examine the overall discriminatory power of i-Index, and Ts lateral-septum to predict LV volume and clinical responses. LVESV decreased .15% in 58% of 106 patients at 6-month follow up. The area under the curves of i-Index for LV volumeresponses to CRT was 0.86, and these was greater than those of Ts lateral-septum for the CRT response outcomes of 0.75. And more responders were included in the opposite sided lead positioning group. We conclude that i-Index can be a complementary measure for better CRT patient selection and RV and LV leads should be implanted at opposite site around the LV for good prognosis after CRT.
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[Journal Article] Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin,cyclophosphamide, and 5-fluorouracil inwomen with breast cancer2012
Author(s)
Kitagawa K, Kawada K, Morita S, Inada M, Mitsuma A, Sawaki M, Iino S, Inden Y, Murohara T, Imai T, Ando Y
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Journal Title
Ann Oncol
Volume: 23(3)
Pages: 743-7
DOI
Peer Reviewed
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[Journal Article] Rate-dependent shortening of action potential duration increases ventricular vulnerability infailing rabbit heart2011
Author(s)
Harada M, Tsuji Y, Ishiguro YS, Takanari H, Okuno Y, Inden Y, Honjo H, Lee JK, Murohara T, Sakuma I, Kamiya K, Kodama I
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Journal Title
Am J PhysiolHeart Circ Physiol
Volume: 300(2)
Pages: H565-73
DOI
Peer Reviewed
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[Journal Article] Combined assessment of left ventricular dyssynchrony and contractility by speckled tracking strainimaging: a novel index for predictingresponders to cardiac resynchronization therapy2010
Author(s)
Inden Y, Ito R, Yoshida N, Kamiya H, Kitamura K, Kitamura T, Shimano M, Uchikawa T, Tsuji Y, Shibata R, Hirai M, Murohara T
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Journal Title
Heart Rhythm
Volume: 7(5)
Pages: 655-61
DOI
Peer Reviewed
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[Journal Article] Electrocardiographic and electrophysiological characteristics in idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle: relevance for catheter ablation.2010
Author(s)
Yamada T, Doppalapudi H, McElderry HT, Okada T, Murakami Y, Inden Y, Yoshida Y, Yoshida N, Murohara T, Epstein AE, Plumb VJ, Litovsky SH, Kay GN
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Journal Title
Circ Arrhythm Electrophysiol
Volume: 3(4)
Pages: 3(4)
DOI
Peer Reviewed
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