2012 Fiscal Year Final Research Report
Evaluating the mechanisms of right ventricular remodeling after left ventricular myocardial infarction
| Project/Area Number |
22590780
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Mie University |
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Principal Investigator |
DOHI Kaoru 三重大学, 大学院・医学系研究科, 助教 (50422837)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masaaki 三重大学, 大学院・医学系研究科, 教授 (00223181)
TANABE Masaki 三重大学, 医学部附属病院, 講師 (50456737)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床心血管病態学 |
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| Research Abstract |
We evaluated the right ventricular (RV) function in dogs with left ventricular (LV) myocardial infarction (MI) generated by permanent occlusion of left coronary artery using 50μm microspheres. Ventricular contractility and relaxation were impaired, and myocardial fibrosis were prominent both in the left and right ventricles in dogs with MI (6 weeks after onset) compared with normal dogs whereas pulmonary artery pressure was similar in the both groups. These results may shed new light on the causal mechanism of RV remodeling after LVMI.
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