Establishment of evidence on the pathophysiology and treatment in Japanese patients with acute myocardial infarction

2014 Fiscal Year Final Research Report

• Project/Area Number: 22590785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: KOJIMA Sunao 熊本大学, 医学部附属病院, 准教授 (50363528)
• Research Collaborator: ISHIHARA Masaharu ; KOSUGE Masami ; ISHII Hideki ; MASUNAGA Nobutaka ; FUJII Noriyuki ; NAKAMURA Mashio ; HIGUMA Takumi ; HORII Manabu ; FUKUNAGA Takashi ; KOSHO Hideyasu ; TAKANO Hitoshi ; FUJII Kenichi
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 急性心筋梗塞 / レジストリー

Outline of Final Research Achievements

The incidence of acute myocardial infarction (AMI) in Japan has increased until 2000; however, in the US, it has decreased since before 2000. Currently, there is no national registry data related to AMI in Japan, on a municipal or prefectural level. We established the Kumamoto Acute Coronary Events study group to examine the accurate incidence of AMI in the Kumamoto Prefecture by registering all cases and studying recent trends. The number of people with advanced age in Kumamoto Prefecture has gradually increased. In 2004-2011, 8,131 AMI patients were registered; age-adjusted AMI incidence in men decreased from 93.1 in 2004 to 70.7 in 2011 (P=0.0294). Age-adjusted in-hospital cardiac death rate was maintained at ~7%; however, all-cause mortality and non-cardiac death rate increased and appeared to be related. A steady trend of decreasing AMI incidence was observed. Urgent measures should be established against non-cardiac mortality in this era of an aging population.

Free Research Field

循環器内科学