2012 Fiscal Year Final Research Report
Optical imaging studies of the generation of atrial arrythmia evoked by abnormal automatism
| Project/Area Number |
22590787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SAKAI Tetsuro 琉球大学, 医学研究科, 教授 (40153845)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 光イメージング / 膜電位感受性色素 / 心房 / 不整脈 / カオス / event-to-event variations |
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| Research Abstract |
Using optical imaging methods together with voltage-sensitive dye, we analyzed spatio-temporal patterns of excitation spread during the tachycardia-like excitation evoked by electrical stimulation in the isolated rat atrium. Event-to-event variations, which seem to result from physiologically trivial difference(s) of the initial conditions,were always observed among the excitation spread patterns. Based on these results, we consider that tachycardia-like excitation is an example of a spatio-temporal chaos in the physiological system.
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