Efficacy of Auto-PBACT combined with ICD implantation in cardiac anyloidosis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: OGAWA Kazuei 福島県立医科大学, 医学部循環器・血液内科学講座, 教授 (40423800)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Hitoshi 福島県立医科大学, 医学部, 准教授 (10347213) ; TAKEISHI Yasuchika 福島県立医科大学, 医学部, 教授 (40272067) ; TAKANO Masumi 福島県立医科大学, 医学部, 助教 (60398344)
• Project Period (FY): 2010 – 2012
• Keywords: 致死性不整脈 / 再生医療

Research Abstract

Cardiac amyloidosis is a disease having an extremely poor prognosis, and no effective treatments have been established to date. In the present study, after first implanting an implantable cardioverter-defibrillator to prevent early death associated withventricular arrhythmia, we performed and investigated the usefulness of autologous peripheral blood stem cell transplantation in patients with cardiac amyloidosis. Three among the five patients with cardiac amyloidosis for whom we have thus far performed autologous peripheral blood stem cell transplantation have achieved long-term survival, suggesting the potential usefulness of this treatment.

Research Products

• [Journal Article] A Japanese case of chronic lymphocytic leukemia with t(1;6) (2012)
  • Author(s): Harada K, Ikeda K, Matsumoto H, Furukawa M, Takahashi H, Ohkawara H, Noji H, Tasaki K, Abe M, Ogawa K, Takeishi Y
  • Journal Title: Exp Hematol Oncol Volume: 1 (1) Pages: 28
• [Journal Article] Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation (2012)
  • Author(s): Ngoma A, Ikeda K, Hashimoto Y, Mochizuki K, Takahashi H, Sano H, Matsumoto H, Noji H, Saito S, Kikuta A, Ogawa K, Ohtsuka M, Abe M, Nollet K, Ohto H
  • Journal Title: Int J Hematol Volume: 95 (1) Pages: 86-94
• [Journal Article] Maturity-dependent fractionation of neutrophil progenitors: A new method to examine in vivo expression profiles of differentiation-regulating genes. (2012)
  • Author(s): Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
  • Journal Title: Exp Hematol Volume: 40 (8) Pages: 675-681
• [Journal Article] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients. (2011)
  • Author(s): Shikama Y, XiaoMin F, Shichishima T, Ono T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
  • Journal Title: Br J Haematol Volume: 154 (4) Pages: 525-527
• [Journal Article] A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation (2010)
  • Author(s): Ogawa K, Ikeda K, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Hashimoto Y, Asahi K, Noji H, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 (2) Pages: 151-156
• [Journal Article] Attenuation of ischemic myocardial injury and dysfunction by cardiac fibroblast-derived factor(s). (2010)
  • Author(s): Nakazato K, Naganuma W, Ogawa K, Yaoita H, Mizuno S, Nakamura T, Maruyama Y
  • Journal Title: Fukushima J Med Sci Volume: 56 (1) Pages: 1-16
• [Journal Article] Hematopoietic stem cell transplantation in the department of hematology, Fukushima Medical University (2010)
  • Author(s): Ogawa K, Noji H, Furukawa M, Harada-Shirado K, Mashimo Y, Takahashi H, Matsumoto H, Kimura S, Shichishima-Nakamura A, Ohkawara H, Ikeda K, Ohto H, Takeishi Y
  • Journal Title: Fukushima J Med Sci Volume: 56 (2) Pages: 107-114
• [Presentation] Expression of let-7 micro RNAs in transgenic ΔHmga2 mice (2012)
  • Author(s): Ikeda K, Harada K, Ogawa K, Mason P, Bessler M, Takeishi Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20121019-21
• [Presentation] Kinetics of regulatory T cell after allogeneic hematopoietic stem cell transplantation (2012)
  • Author(s): Ikeda K, Mashimo Y, Ngoma A, Matsumoto H, Hashimoto Y, Kikuta A, Ogawa K, Abe M, Ohto H, Takeishi Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20121019-21
• [Presentation] Morphologic and cytogenetic examinations with bone marrow cells in PNH patients (2012)
  • Author(s): Noji H, Hamanaka S, Yamaguchi K, Ogawa K, Murai K, Kimura H, Mita M, Suzuki I, Kohno K, Kimura S, Saitoh Y, Hatta S, Michishita Y, Kanbayashi H, Ishida Y, Harigae H, Sawada K, Takeishi Y, Shichishima T
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20121019-21
• [Presentation] Mechanism of impaired FOS mRNA induction by emetine in myelodysplastic syndrome granulocytes (2012)
  • Author(s): Feng X, Shikama Y, Noji H, Shichishima T, Ikeda K, Ogawa K, Takeishi Y, Kimura J
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20121019-21
• [Presentation] Multicentric Castleman's disease in the familial autoimmune endocrine disorders (2012)
  • Author(s): Harada K, Ikeda K, Minemura H, Tanino Y, Hashimoto Y, Munakata M, Abe M, Ogawa K, Takeishi Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20121019-21
• [Presentation] IRF4 に関連した染色体転座T(1;6)を有した慢性リンパ性白血病の一例 (2012)
  • Author(s): 原田佳代, 池田和彦, 松本勇人, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 田崎和洋, 小川一英, 阿部正文, 竹石恭知
  • Organizer: 第52回日本リンパ網内系学会総会
  • Place of Presentation: 福島
  • Year and Date: 20120614-16
• [Presentation] 造血幹細胞移植後における制御性T細胞の動態に関する検討 (2012)
  • Author(s): 池田和彦, ンゴマ アライン, 斎藤俊一, 小川一英, 菊田敦, ノレット ケネス, 大戸斉
  • Organizer: 第60回日本輸血・細胞治療学会総会
  • Place of Presentation: 郡山
  • Year and Date: 20120525-27
• [Presentation] MPN-like hematopoiesis and a clonal advantage of an HSC caused by 3'UTR-truncated Hmga2 cDNA in mice (2011)
  • Author(s): Ikeda K, Mason P, Ogawa K, Takeishi Y, Bessler M
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111014-16
• [Presentation] Outcome after first relapse in adult patients with Ph-negative acute lymphoblastic leukemia (2011)
  • Author(s): Kako S, Kanamori H, Kobayashi N, Shigematsu A, Nannya Y, Nakamae M, Shigeno K, Suzukawa K, Takeuchi M, Tsuzuki M, Usuki K, Hatanaka K, Ogawa K, Mitani K, Nawa Y, Mizuno I, Kanda Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111014-16
• [Presentation] Phasell Study of Dasatinib safety and efficacy for CP-CML at Tohoku (2011)
  • Author(s): Akagi T, Murai K, Shimosegawa K, Ishizawa K, Sugawara T, Yokoyama H, Noji H, Ogawa K, Tajima K, Miyashita Y, Ooba K, Sakamoto J, Kubo K, Harigae H, Ishida Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111014-16
• [Presentation] PNH-type cells by flow cytometric methods with a monoclonal antibody and FLAER in BMFS patients (2011)
  • Author(s): Takahashi H, Shichishima T, Noji H, Ogawa K, Takeishi Y
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111014-16
• [Presentation] 自家末梢血幹細胞移植後にサイトメガロウイルス感染が原因と考えられた血球貪食症候群の2 例6. (2011)
  • Author(s): 松本勇人, 古川未希, 原田佳代, 真下由美子, 高橋裕志, 木村哲, 七島晶子, 大河原浩, 野地秀義, 小川一英, 大戸斉, 竹石恭知
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 松山
  • Year and Date: 20110309-10
• [Presentation] Management of Oral Care for the patient with Hematoropoie Stem Cell Transplantation-Cooperate with a dentist and a dental hygienist.7. (2011)
  • Author(s): 澤原由美子, 鈴木里枝, 新田文都, 鈴木浩美, 遠藤裕子, 小川一英
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 松山
  • Year and Date: 20110309-10
• [Presentation] Impaired c-fos induction by emetin in granulocytes from myelodysplastic syndrome patients. 臨床血液 (2010)
  • Author(s): Feng X, Shikama Y, Shichishima T, Noji H, Ogawa K, Takeishi Y
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20100924-26
• [Presentation] 血液学的およびクローン性寛解に至った発作性夜間ヘモグロビン尿症の2症例 (2010)
  • Author(s): 古川未希, 野地秀義, 七島勉, 原田佳代, 眞下由美子, 高橋裕志, 松本勇人, 木村哲, 七島晶子, 大河原浩, 小川一英, 竹石恭知
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20100924-26
• [Presentation] Analysis of autologous PBSCT in four patients with cardiac amyloidosis (2010)
  • Author(s): Ogawa K, Kimura S, Furukawa M, Harada K, Mashimo Y, Takahashi H, Matsumoto H, Shichishima-Nakamura A, Ohkawara H, Noji H, Shichishima T, Ohto H, Takeishi Y
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20100924-26
• [Presentation] 急性骨髄性白血病へ移行した骨髄異形成症候群を合併した発作性夜間ヘモグロビン尿症の一例 (2010)
  • Author(s): 木村哲, 野地秀義, 七島勉, 大河原浩, 古川未希, 原田佳代, 眞下由美子, 高橋裕志, 松本勇人, 七島晶子, 小川一英, 竹石恭知
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20100924-26