Development of spectroscopy using next generation frequency-domain optical coherence tomography and assessment of the treatment of vulnerable plaque by this newly developed technique.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: TAKASHI Akasaka 和歌山県立医科大学, 医学部, 教授 (70322584)
• Co-Investigator(Kenkyū-buntansha): TANIMOTO Takashi 和歌山県立医科大学, 医学部, 助教 (90438284) ; MURAGAKI Yasumitsu 和歌山県立医科大学, 医学部, 教授 (40190904)
• Project Period (FY): 2010 – 2012
• Keywords: 臨床心血管病態学

Research Abstract

Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences has been developed anddescribed in a literature, and it is now applicable for three-dimensional reconstruction of coronary artery images in newly developed frequency-domain OCT system, althoughspectroscopic analysis system of coronary plaques are still under -developing at the moment. Identification of vulnerable plaques by characteristics of gray-scale OCT images have been reported in many literatures, and further investigation using spectroscopic analysis would be performed in the near future after completely developing the spectroscopy analysis in newly developed frequency-domain OCT system.

Research Products

• [Journal Article] Coronary Superficial and Spotty Calcium Deposits in Culprit Coronary Lesions of Acute Coronary Syndrome as Determined by Optical Coherence Tomography (2013)
  • Author(s): Mizukoshi M, Kubo T, Takarada S, Kitabata H, Ino Y, Tanimoto T, Komukai K, Tanaka A, Imanishi T, Akasaka T
  • Journal Title: Am J Cardiol
  • DOI: DOI:10.1016/j.amjcard.2013.02.048
• [Journal Article] Consensus standards s standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the international working group for intravascular optical coherence tomography standardization and validation (2012)
  • Author(s): Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, et al
  • Journal Title: J Am Col Cardiol Volume: 59(12) Pages: 1058-1072
• [Journal Article] Diverse role of macrophages in atheroscrelosis: from inflammatory biology to biomarkerdiscovery (2012)
  • Author(s): Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  • Journal Title: Mediators Inflamm
  • DOI: DOI:10.1155/2012/693083
• [Journal Article] Automatic detection of stent struts with thick neointimal growth in intravascular optical coherence tomography image sequences (2011)
  • Author(s): Xu C, Schmitt JM, Akasaka T, Kubo T, Huang K
  • Journal Title: Phys Med Biol Volume: 56(20) Pages: 6665-6675
• [Journal Article] Thin-cap fibroatheroma as high risk plaque for microvascular obstruction in patients with acute coronary syndrome (2011)
  • Author(s): Ozaki Y, Tanaka A, Tanimoto T, Kitabata H, Kashiwagi M, Kubo T, Takarada S, Ishibashi K, Komukai K, Ino Y, Hirata K, Mizukoshi M, Imanishi T, Akasaka T
  • Journal Title: Circ Cardiovasc Imag Volume: 4(6) Pages: 620-627
• [Journal Article] Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic angina (2011)
  • Author(s): Tanaka A, Shimada K, Tearney G. J, Kitabata H, Taguchi H, Fukuda S, Kashiwagi M, Kubo T, Takarada S, Hirata K, Mizukoshi M, Yoshikawa J,Bouma B.E, Akasaka T
  • Journal Title: J Am Coll Cardiol Volume: 58(15) Pages: 1608-1613
• [Journal Article] Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion (2010)
  • Author(s): Takarada S, Imanishi T, Liu Y, Ikejima H, Tsujioka H, Kuroi A, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Kitabata H, Kubo T, Nakamura N, Hirata K, Tanaka A, Mizukoshi M, Akasaka T
  • Journal Title: Catheter Cardiovasc Interv Volume: 75(2) Pages: 202-206
• [Journal Article] Clinical classification and plaque morphology determined by optical coherence tomography in unstable angina pectoris (2010)
  • Author(s): Mizukoshi M, Imanishi T, Tanaka A, Kubo T, Liu Y, Takarada S, Kitabata H, Tanimoto T, Komukai K, Ishibashi K, Akasaka T
  • Journal Title: Am J Cadiol Volume: 106(3) Pages: 323-328
• [Journal Article] The effect of lipid and inflammatory profiles on the morphological changes of lipid-rich plaques in patients with non-STsegment elevated acute coronary syndrome: follow-up study by optical coherence tomography and intravascular ultrasound (2010)
  • Author(s): Takarada S, Imanishi T, Ishibashi K, Tanimoto T, Komukai K, Ino Y, Kitabata H, Kubo T, Tanaka A, Kimura K, Mizukoshi M, Akasaka T
  • Journal Title: J Am Coll Cardiol Interv Volume: 3(7) Pages: 766-772
• [Journal Article] Pathophysiology of acute coronary syndrome assessed by optical coherence tomography (2010)
  • Author(s): Akasaka T, Kubo T, Mizukoshi M, Tanaka A, Kitabata H, Tanimoto T, Imanishi T
  • Journal Title: J Cardiol Volume: 56(1) Pages: 8-14
• [Presentation] Effect of intensive vs. moderate lipidlowering therapy with atorvastatin on the stabilization of atherosclerosis in acute coronary syndromes - serial optical coherence tomography analysis (2012)
  • Author(s): Akasaka T, Komukai K, Ishibashi K, Tanimoto T, Matsuo Y, Ino Y, Kitabata H, Kubo T, Tanaka A,Imanishi T
  • Organizer: European Society of Cardiology 2012
  • Place of Presentation: Munich, German
  • Year and Date: 20120800
• [Presentation] OCT Plaque characterization predicts clinical events (2012)
  • Author(s): Akasaka T
  • Organizer: 10th Vulnerable Patient Meeting
  • Place of Presentation: Attica, Greece
  • Year and Date: 20120600
• [Presentation] How to measure fibrous cap thickness and what does that teach us? (2011)
  • Author(s): Akasaka T
  • Organizer: Optics in Cardiology
  • Place of Presentation: Rotterdam, The Netherlands
  • Year and Date: 20111200
• [Presentation] Present status and future perspective of optical coherence tomography (2011)
  • Author(s): Akasaka T
  • Organizer: 16th World Congress on Heart Disease
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20110700
• [Presentation] Pathophysiology of acute coronary syndrome assessed by OCT (2010)
  • Author(s): Akasaka T
  • Organizer: The 4th Imaging & Physiology Summit 2010
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20101000
• [Presentation] Vulnerable plaque: emerging directions for diagnosis and treatment (2010)
  • Author(s): Akasaka T
  • Organizer: Transcatheter Cardiovascular Therapeutics 2010
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20100800
• [Presentation] Can optical coherence tomography predict plaque vulnerability? (2010)
  • Author(s): Akasaka T
  • Organizer: Euro PCR
  • Place of Presentation: Paris, France
  • Year and Date: 20100500
• [Presentation] The Relationship between the plaque morphology of culprit lesions and clinical presentations of ACS patients (2010)
  • Author(s): Ino Y, Kitabata H, Kubo T, Tanaka A, Komukai K, Tanimoto T, Ishibashi K, Masuno T, Takarada S, Shimokado A, Kuroi A, Hirata K, Kimura K, MizukoshiM, Imanishi T, Akasaka T
  • Organizer: an optical coherence tomography study. American College of Cardiology 59th Annual Scientific Session
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20100300
• [Presentation] Clinical presentation and plaque morphology in unstable angina pectoris: an optical coherence tomography study (2010)
  • Author(s): Mizukoshi M, Kubo T, Tanaka A, Takarada S, Kitabata H, Tanimoto T, Kuroi A, Ikejima H, Komukai K, Ino Y, Tsujioka H, Okochi K, Kashiwagi M, Ozaki Y, Shimokado A, Hirata K, Imanishi T, Akasaka T
  • Organizer: American College of Cardiology 59thAnnual Scientific Session
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20100300
• [Presentation] Detection and responses to treatment of unstable plaques assessed by OCT (2010)
  • Author(s): Akasaka T
  • Organizer: APSC-JCS Joint Symposium, The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kyoto
  • Year and Date: 20100300
• [Book] Chourmouzios Arampatzis, Eugene P. McFadden, Lampros K. Michalis, Renu Virmani and Patrick W. Serruys editors. Coronary Atherosclerosis, first edition: Current Management and Treatment (2013)
  • Author(s): Kubo T, Akasaka T
  • Publisher: Informa Healthcare
• [Book] 7. OCTによるプラーク診断. III. 診断と治療-最新の進歩 A.虚血性心疾患.「Annual Review 循環器 2011」 山口 徹,高本眞一,小室一成, 佐地 勉編 (2011)
  • Author(s): 石橋耕平, 北端宏規, 赤阪隆史
  • Total Pages: 366
  • Publisher: 中外医学社
• [Book] Identification of vulnerable plaques with optical coherence tomography. In: Ksenija Pesek. Atherosclerotic Cardiovascular Disease (2011)
  • Author(s): Kubo T, Akasaka T
  • Total Pages: 124
  • Publisher: InTech - Open Access Publisher Rijeka
• [Book] sixth edition, edited by Topol Eric J, Teirstein Paul S, Optical coherence tomography. Textbook of Interventional Cardiology (2011)
  • Author(s): Guagliumi G, Akasaka T, Sirbu V, Kubo T
  • Total Pages: 928
  • Publisher: ERSEVIER, Missouri, USA
• [Book] 冠動脈イメージングがとらえる冠動脈病変. 最新医学・別冊 新しい診断と治療の ABC 69 / 循環器 12 狭心症 (2010)
  • Author(s): 谷本貴志, 水越正人, 赤阪隆史
  • Total Pages: 268
• [Remarks] 研究成果記載
  • URL: http://www.wakayama-med.ac.jp