Wound healing response in injured vessel wall after implantationof drug-eluting stents

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Dokkyo Medical University
• Principal Investigator: INOUE Teruo 獨協医科大学, 医学部, 教授 (20168454)
• Co-Investigator(Kenkyū-buntansha): ABE Shichiro 獨協医科大学, 医学部, 教授 (80275718) ; TAGUCHI Isao 獨協医科大学, 医学部, 准教授 (80316570) ; SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199) ; NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
• Co-Investigator(Renkei-kenkyūsha): SAKUMA Masashi 佐賀大学, 医学部, 医員 (10530199) ; NODE Koichi 佐賀大学, 医学部, 教授 (80359950)
• Project Period (FY): 2010 – 2012
• Keywords: 臨床心血管病態学 / 分子血管病態学

Research Abstract

In this study, we investigated wound healing process after stent-induced vascular injury in the second generation drug-eluting stent (DES) such as zotarolimus-eluting stent (ZES) and everolimus-eluting stent (EES) and compared with bare metal stent (BMS) or the first generation DES. The BMS induced mobilization of endothelial progenitor cells (EPCs) that leads to re-endothelialization in the injured vessel wall. However, ZES as well as EES substantially inhibited the EPC mobilization and re-endothelialization, possibly leading to relapse and prolongation of inflammatory reaction at late phase. even second generation DESs remain problematic in terms of the wound healing process after vascular injury.

Research Products

• [Journal Article] Late phase inflammatory response as a feature of in-stent restenosis after drug-eluting stent implantation (2013)
  • Author(s): Yoneda S, Abe S, Kanaya T, Oda K, Nishino S, Kageyama M, Taguchi I, Masawa N, Inoue T
  • Journal Title: Coron Artery Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Pathological features of in-stent restenosis after sirolimus-eluting stent vs. bare metal stent placement (2012)
  • Author(s): Abe S, Yoneda S, Kanaya T, Oda K, Nishino S, Kageyama M, Taguchi I, Masawa N, Inoue T
  • Journal Title: Cardiovasc Pathol Volume: 21 Pages: 19-22
  • DOI: DOI:10.1016/j.carpath.2011.02.003
  • Peer Reviewed
• [Journal Article] Inflammation and impaired wound healing after zotarolimus-eluting stent implantation (2012)
  • Author(s): Yoneda S, Abe S, Taguchi I, Masawa N, Inoue K, Inoue T
  • Journal Title: Cardiovasc Pathol Volume: 21 Pages: 511-514
  • DOI: DOI:10.1016/j.carpath.2012.01.003
  • Peer Reviewed
• [Journal Article] Vascular inflammation and repair: implication for reendothelialization, restenosis, and stent thrombosis. (2011)
  • Author(s): Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI
  • Journal Title: J Am Coll Cardiol Intv Volume: 4 Pages: 1057-1066
  • DOI: DOI:10.1016/j.jcin.2011.05.025
  • Peer Reviewed
• [Journal Article] The late phase inflammatory response after drug-eluting stent implantation
  • Author(s): Taguchi I, Yoneda S, Abe S, Toyoda S, Nasuno T, Nishino S, Kageyama M, Tokura M, Ogawa M, Node K, Inoue T
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/23649933
  • Peer Reviewed