2012 Fiscal Year Final Research Report
Vagal stimulation, a novel therapeutic approach for cardiovascular regeneration
| Project/Area Number |
22590799
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
LI Meihua 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (60443496)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Masashi 独立行政法人国立循環器病研究センター, 研究所, 室長 (80359273)
ZHENG Can 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (50443495)
KAWADA Toru 独立行政法人国立循環器病研究センター, 研究所, 室長 (30243752)
UEMURA Kazunori 独立行政法人国立循環器病研究センター, 研究所, 室長 (10344350)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 急性心筋梗塞 / 慢性心不全 / 迷走神経刺激 / 心血管新生 / 心臓リモデリング |
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| Research Abstract |
We have demonstrated that vagal stimulation (VS) prevented the cardiac remodeling and death in post-myocardial infarction rats. However, the precise mechanisms of cardiac protection by VS have not been fully elucidated. To develop a novel cardiovascular regeneration therapy with vagal stimulation (VS), this study examined the role of VS on activation of endogenous cardiac stem cells (CSCs) after acute myocardial infarction. The results suggested that the preservation of cardiac function by VS in AMI rats maybe mediated partly by activation of CSCs and induction of angiogenesis.
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