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2012 Fiscal Year Final Research Report

Analysis of regulatory T cells and helper T cells in myocarditis and its application to the therapy for inflammatory cardiovascular diseases.

Research Project

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Project/Area Number 22590805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNiigata University

Principal Investigator

KODAMA Makoto  新潟大学, 医歯学系, 准教授 (10242447)

Project Period (FY) 2010 – 2012
Keywords内科 / 免疫学 / 心筋炎 / Th17
Research Abstract

Alterations of IL-17-related protein expressions were investigated. The results showed thatIL-17 was expressed more highly than IFN-gamma expressed by Th1 cells in alpha/beta T cells and the peaks of IL-17 related protein expression in the heart were the early phase of EAM. Then we focused on helper T cell differentiation in allogenic FM-MSC administered EAM rats. Administration of FM-MSC improved left ventricular ejection fraction. The percentage of Th1 cells and Th17 cells were significantly reduced by FM-MSC administration. Thus, intravenous administration of allogenic FM-MSCs ameliorates EAM via the suppression of Th1/Th17 immunity.

  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (19 results) (of which Peer Reviewed: 19 results)

  • [Journal Article] Estimation of paracrine signaling using quantitative RT-PCR from multiple patchy lesion samples2013

    • Author(s)
      Jiao S, Hanawa H, Suzuki T, Hu YH,Yoshida K, Ogura M, Ohno Y, Ito M, Kashimura T, Obata H, Kodama M
    • Journal Title

      MolCell Probes

      Volume: 27 Pages: 109-113

    • Peer Reviewed
  • [Journal Article] Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signaling2012

    • Author(s)
      Arumugam S, Thandavarayan AR, Arozal W, Sari RF, Giridharan VV, Soetikno V, Palaniyandi SS, Harima M, Suzuki K, Nagata M, Takagi R, Kodama M, Watanabe K
    • Journal Title

      Free Radical Research

      Volume: 46 Pages: 154-163

    • Peer Reviewed
  • [Journal Article] Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis2012

    • Author(s)
      Ohshima M, Yamahara K, Ishikane S,Harada K, Tsuda H, Otani K, TaguchiA, Miyazato M, Katsuragi S, Yoshimatsu J, Kodama M, Kangawa K,Ikeda T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 53(3) Pages: 420-8

    • Peer Reviewed
  • [Journal Article] Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy2012

    • Author(s)
      Arumugam S, Thandavarayan RA,Veeraveedu PT, Nakamura T, Arozal W, Sari FR, Giridharan VV, Soetikno V, Palaniyandi SS, Harima M, Suzuki K, Nagata M, Kodama M, Watanabe K
    • Journal Title

      J Cell Mol Med

      Volume: 16(9) Pages: 2176-85

    • Peer Reviewed
  • [Journal Article] Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats2012

    • Author(s)
      Arumugam S, Thandavarayan RA,Veeraveedu PT, Ma M, Giridharan VV, Arozal W, Sari FR, Sukumaran V,Lakshmanan A, Soetikno V, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      J Clin Biochem Nutr

      Volume: 50(2) Pages: 139-44

    • Peer Reviewed
  • [Journal Article] Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor2012

    • Author(s)
      Sukumaran V, Veeraveedu PT, Lakshmanan AP, Gurusamy N, Yamaguchi K, Ma M, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      Free Radic Res

      Volume: 46(7) Pages: 850-60

    • Peer Reviewed
  • [Journal Article] Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant2012

    • Author(s)
      Arumugam S, Thandavarayan RA, Veeraveedu PT, Giridharan VV,Soetikno V, Harima M, Suzuki K, Nagata M, Tagaki R, Kodama M, Watanabe K
    • Journal Title

      Exp Mol Pathol

      Volume: 93(2) Pages: 183-9

    • Peer Reviewed
  • [Journal Article] Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis2012

    • Author(s)
      Sukumaran V, Veeraveedu TP, Gurusamy N, Lakshmanan PA, Yamaguchi K, Ma M, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      Life Sciences

      Volume: 90 Pages: 289-300

    • Peer Reviewed
  • [Journal Article] Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis2012

    • Author(s)
      Arumugam S, Thandavarayan AR, Palaniyandi SS, Giridharan VV, Arozal W, Sari RF, Soetikno V, Harima M, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      Toxicology

      Volume: 291 Pages: 139-145

    • Peer Reviewed
  • [Journal Article] Experimental autoimmune myocarditis: role of renin angiotensin system2011

    • Author(s)
      Watanabe K, Arumugam S, Thandavarayan AR, Kodama M
    • Journal Title

      Myocarditis. Edited by Daniela Cihakova, InTech - Open Access Publisher

      Pages: 309-320

    • Peer Reviewed
  • [Journal Article] Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis2011

    • Author(s)
      Mito S, Thandavarayan RA, Ma M, Lakshmanan A, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      Free Radical Res

      Volume: 45 Pages: 1223-1231

    • Peer Reviewed
  • [Journal Article] Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis2011

    • Author(s)
      Mito S, Watanabe K, Harima M, Thandavarayan RA, Veeraveedu PT, Sukumaran V, Suzuki K, Kodama M, izawa Y
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 974-979

    • Peer Reviewed
  • [Journal Article] A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy2011

    • Author(s)
      Kamal FA, Watanabe K, Ma M, Abe Y, Elbarbary R, Kodama M, Aizawa Y
    • Journal Title

      Heart Vessels

      Volume: 26 Pages: 81-90

    • Peer Reviewed
  • [Journal Article] Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/Mas receptor axis2011

    • Author(s)
      Sukumaran V, Veeraveedu TP, Gurusamy N, Yamaguchi K, Lakshmanan PA, Ma M, Suzuki K, Kodama M, Watanabe K
    • Journal Title

      Int J Biol Sci

      Volume: 7 Pages: 1077-1092

    • Peer Reviewed
  • [Journal Article] Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts2011

    • Author(s)
      Hao K, Hanawa H, Ding L, Ota Y, Yoshida K, Toba K, Ogura M, Ito H, Kodama M, Aizawa Y
    • Journal Title

      Mol Immunol

      Volume: 48 Pages: 1191-1202

    • Peer Reviewed
  • [Journal Article] Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by xperimental autoimmune myocarditis2011

    • Author(s)
      Sukumaran V, Watanabe K, Veeraveedu TP, Gurusamy N, Ma M, Yamaguchi K, Suzuki K, Kodama M, Aizawa Y
    • Journal Title

      Int J Biol Sci

      Volume: 7 Pages: 154-167

    • Peer Reviewed
  • [Journal Article] Sulfated polysaccharide fucoidan ameliorates experimental autoimmune myocarditis in rats2011

    • Author(s)
      Tanaka K, Ito M, Kodama M, TomitaM, Kimura S, Hoyano M, Mitsuma W, Hirono S, Hanawa H, Aizawa Y
    • Journal Title

      J Cardiovasc Pharmacol Ther

      Volume: 16 Pages: 79-86

    • Peer Reviewed
  • [Journal Article] IL-1 receptor accessory protein-Ig/IL-1 receptor type II-Ig heterodimer inhibits IL-1 response more strongly than other IL-1 blocking biopharmaceutical agents2011

    • Author(s)
      Hanawa H, Ota Y, Ding L, Chang H, Yoshida K, Otaki K, Hao K, Kasahara S, Kodama M, Nakazawa M, Aizawa Y
    • Journal Title

      J Clin Immunol

      Volume: 31 Pages: 455-464

    • Peer Reviewed
  • [Journal Article] Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress2011

    • Author(s)
      Sukumaran V, Watanabe K, Veeraveedu PT, Ma M, Gurusamy N, Rajavel V, Suzuki K, Yamaguchi K, Kodama M, Aizawa Y
    • Journal Title

      Eur J Pharmacol

      Volume: 652 Pages: 126-135

    • Peer Reviewed

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Published: 2014-08-29  

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