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2012 Fiscal Year Final Research Report

Research of the tailor-maid treatment of hypertrophic and dilated cardiomyopathy by comprehensive genetic analysis

Research Project

  • PDF
Project/Area Number 22590808
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKanazawa University

Principal Investigator

FUJINO Noboru  金沢大学, 保健学系, 准教授 (40361993)

Co-Investigator(Kenkyū-buntansha) HAYASHI Kenshi  金沢大学, 大学病院, 助教 (00422642)
YAMAGISHI Masakazu  金沢大学, 医学系, 教授 (70393238)
Project Period (FY) 2010 – 2012
Keywords肥大型心筋症 / 収縮不全 / 拡張型心筋症 / 遺伝子 / 遺伝学 / 循環器 / 高血圧
Research Abstract

The study included 157 sarcomere gene mutation carriers, and 107 subjects underwent serial echocardiograms. At a mean follow-up of 7 years, 12 subjects experienced systolic dysfunction. When the subjects were divided into MYBPC3 and non-MYBPC3 mutation carriers, the rate of systolic dysfunction was higher in the non-MYBPC3 group than in MYBPC3 group.

  • Research Products

    (11 results)

All 2013 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Impact of systolic dysfunction in genotyped hypertrophic cardiomyopathy2013

    • Author(s)
      Fujino N, Konno T, Hayashi K, Hodatsu A, Fujita T, Tsuda T, Nagata Y, Kawashiri MA, Ino H, Yamagishi M
    • Journal Title

      Clin Cardiol

      Volume: 36 Pages: 160-165

    • DOI

      DOI:10.1002/clc.22082

    • Peer Reviewed
  • [Journal Article] A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome2013

    • Author(s)
      Liu L, Hayashi K, Kaneda T, Ino H, Fujino N, Uchiyama K, Konno T, Tsuda T, Kawashiri MA, Ueda K, Higashikata T, Shuai W, Kupershmidt S, Higashida H, Yamagishi M
    • Journal Title

      Heart Rhythm

      Volume: 10 Pages: 61-67

    • DOI

      DOI:10.1016/j.hrthm.2012.09.053

    • Peer Reviewed
  • [Journal Article] Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B2011

    • Author(s)
      Demura M, Wang F, Yoneda T, Karashima S, Mori S, Oe M, Kometani M, Sawamura T, Cheng Y, Maeda Y, Namiki M, Ino H, Fujino N, Uchiyama K, Tsubokawa T, Yamagishi M, Nakamura Y, Ono K, Sasano H, Demura Y, Takeda Y.
    • Journal Title

      Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues. J Hypertens

      Volume: 29 Pages: 1185-1195

    • DOI

      DOI:10.1097/HJH.0b013e32834626bb.

    • Peer Reviewed
  • [Journal Article] A KCR1 variant implicated in susceptibility to the long QT syndrome2011

    • Author(s)
      Hayashi K, Fujino N, Ino H, Uchiyama K, Sakata K, Konno T, Masuta E, Funada A, Sakamoto Y, Tsubokawa T, Hodatsu A, Yasuda T, Kanaya H, Kim MY, Kupershmidt S, Higashida H, Yamagishi M
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50 Pages: 50-57

    • DOI

      DOI:10.1016/j.yjmcc.2010.10.007.

    • Peer Reviewed
  • [Journal Article] Impact of renin-angiotensin system polymorphisms on development of systolic dysfunction in hypertrophic cardiomyopathy2010

    • Author(s)
      Funada A, Konno T, Fujino N, Muramoto A, Hayashi K, Tsubokawa T, Sakata K, Kawashiri MA, Takeda Y, Ino H, Yamagishi M.
    • Journal Title

      Evidence from a study of genotyped patients. Circ J

      Volume: 74 Pages: 2674-2680

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20975235

    • Peer Reviewed
  • [Journal Article] Heterogeneity of clinical manifestation of hypertrophic cardiomyopathy caused by deletion of lysine 183 in cardiac troponin I gene2010

    • Author(s)
      Funada A, Masuta E, Fujino N, Hayashi K, Ino H, Kita Y, Ikeda H, Fujii T, Nakanuma Y, Yamagishi M
    • Journal Title

      Int Heart J

      Volume: 51 Pages: 214-217

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20558914

    • Peer Reviewed
  • [Presentation] 原因遺伝子変異が確認された肥大型心筋症の心肥大発症年齢2012

    • Author(s)
      藤野 陽
    • Organizer
      第16回日本心不全学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2012-11-30
  • [Presentation] 肥大型心筋症における心肥大発症に関与する遺伝的要因の検討(パネルディスカッション8:心血管疾患発症進展における遺伝・環境的要因)2012

    • Author(s)
      藤野 陽
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2012-09-16
  • [Presentation] Impact of Genetic Analysis on the mode of Death in Genotyped Hypertrophic Cardiomyopathy2011

    • Author(s)
      Fujino N
    • Organizer
      American Heart Association's Scientific Sessions2011
    • Place of Presentation
      Orange County Convention Center(USA)
    • Year and Date
      2011-11-15
  • [Presentation] The Impact of Systolic Dysfunction on Prognosis of Genotyped Hypertrophic Cardiomyopathy2011

    • Author(s)
      Fujino N
    • Organizer
      60th Annual Scientific Session of American College of Cardiology
    • Place of Presentation
      Earnest N. Morial Convention Center(USA)
    • Year and Date
      2011-04-03
  • [Remarks]

    • URL

      http://intmed2.w3.kanazawa-u.ac.jp/index_j.html

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Published: 2014-08-29  

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