2012 Fiscal Year Final Research Report
Elucidation of significance of TRPM2 in progression of heart failure
| Project/Area Number |
22590810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWAHARA Koichiro 京都大学, 大学院・医学研究科, 講師 (30402887)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Yasuo 京都大学, 大学院・工学研究科, 教授 (80212265)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子心臓病学 |
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| Research Abstract |
Angiotensin II-induced cardiac hypertrophy was suppressed in TRPM2knockout mice. In neonatal rat ventricular myocytes, overexpression of TRPM2 enhancedthe promoter activity of BNP and RCAN1 gene. On the other hand, TRPM2 inhibitor suppressedthe promoter activity of BNP and RCAN1 gene. These data suggested that TRPM2 has anacceleratory effect on cardiac hypertrophy.
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Research Products
(66 results)
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[Journal Article] Direct immunochemiluminescent assay for proBNP and total BNPin human plasma proBNP and total BNPlevels in normal and heart failure2013
Author(s)
Nishikimi T, Okamoto H, Nakamura M,Ogawa N, Horii K, Nagata K, NakagawaY, Kinoshita H, Yamada C, Nakao K,Minami T, Kuwabara Y, Kuwahara K,(他4 名)
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Journal Title
PLoSOne
Volume: 8(1)
Pages: e53233
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[Journal Article] inhibition of TRPC6 channel activity contributes to theantihypertrophic effects of natriureticpeptides-guanylyl cyclase-A signaling in theheart2010
Author(s)
Kinoshita H, Kuwahara K, Nishida M, Rong X,Kiyonaka S, Kuwabara Y, Kurose H, Mori Y, LiY, Nakagawa Y,(他6名)
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Journal Title
Circ Res
Volume: 106(12)
Pages: 1849-60
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