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2012 Fiscal Year Final Research Report

Elucidation of significance of TRPM2 in progression of heart failure

Research Project

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Project/Area Number 22590810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

NAKAGAWA Yasuaki  京都大学, 大学院・医学研究科, 助教 (70452357)

Co-Investigator(Kenkyū-buntansha) KUWAHARA Koichiro  京都大学, 大学院・医学研究科, 講師 (30402887)
Co-Investigator(Renkei-kenkyūsha) MORI Yasuo  京都大学, 大学院・工学研究科, 教授 (80212265)
Project Period (FY) 2010 – 2012
Keywords分子心臓病学
Research Abstract

Angiotensin II-induced cardiac hypertrophy was suppressed in TRPM2knockout mice. In neonatal rat ventricular myocytes, overexpression of TRPM2 enhancedthe promoter activity of BNP and RCAN1 gene. On the other hand, TRPM2 inhibitor suppressedthe promoter activity of BNP and RCAN1 gene. These data suggested that TRPM2 has anacceleratory effect on cardiac hypertrophy.

  • Research Products

    (66 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) Presentation (57 results) Remarks (1 results)

  • [Journal Article] Direct immunochemiluminescent assay for proBNP and total BNPin human plasma proBNP and total BNPlevels in normal and heart failure2013

    • Author(s)
      Nishikimi T, Okamoto H, Nakamura M,Ogawa N, Horii K, Nagata K, NakagawaY, Kinoshita H, Yamada C, Nakao K,Minami T, Kuwabara Y, Kuwahara K,(他4 名)
    • Journal Title

      PLoSOne

      Volume: 8(1) Pages: e53233

  • [Journal Article] Complexity of melicular formsof B-type natriuretic peptide in heartfailure2012

    • Author(s)
      Nishikimi T, Kuwahara K, NakagawaY
    • Journal Title

      Heart

  • [Journal Article] Reciprocal expression ofMRTF-A and myocardin in crucial forpathological vascular remodelling inmice2012

    • Author(s)
      Minami T, Kuwahara K, NakagawaY
    • Journal Title

      EMBO J

      Volume: 31(23) Pages: 4428-40

  • [Journal Article] Fixed-dosecombination therapy of candesartancilexetile and amlodipine besilate for thetreatment of hypertension in Japan2012

    • Author(s)
      Yasuno S, Fujimoto A, Nakagawa Y,Kuwahara K, Ueshima K
    • Journal Title

      Expert Rev cardiovasc Ther

      Volume: 10(5) Pages: 577-83

  • [Journal Article] The effect of glycosylation onfplasm N-terminal proBNP-76 levels inpatients with heart or renal failure2012

    • Author(s)
      Nishikimi T, Ikeda M, Takeda Y,Ishimitus T, Shibasaki I, Fukuda H,Kinoshita H, Nakagwa Y, Kuwahara K,Nakao K
    • Journal Title

      Heart

      Volume: 98(2) Pages: 152-61

  • [Journal Article] Zinc-finger protein90 negatively regulates neuron-restritivesilencer factor-mediated transcriptionalrepression of fetal cardiac genes2011

    • Author(s)
      Hata L, Murakami M, Kuwahara K,Nakagawa Y
    • Journal Title

      J MolCell Cardiol

      Volume: 50 (6) Pages: 972-981

  • [Journal Article] Myocardin-relatedtranscriptional factor A is a common mediator ofmechanical stress- and neurohumoralstimulation-induced cardiac hypertrophicsignaling leading to activation of brain natriureticpeptide gene expression2010

    • Author(s)
      Kuwahara K, Kinoshita H, Kuwabara Y,Nakagawa Y
    • Journal Title

      Mol Cel Biol

      Volume: 30(17) Pages: 4134-48

  • [Journal Article] inhibition of TRPC6 channel activity contributes to theantihypertrophic effects of natriureticpeptides-guanylyl cyclase-A signaling in theheart2010

    • Author(s)
      Kinoshita H, Kuwahara K, Nishida M, Rong X,Kiyonaka S, Kuwabara Y, Kurose H, Mori Y, LiY, Nakagawa Y,(他6名)
    • Journal Title

      Circ Res

      Volume: 106(12) Pages: 1849-60

  • [Presentation] Glycosylation of plasma N-terminal proBNP andits effect on NT-proBNP assay in hemodyalysispatients2013

    • Author(s)
      Yasuaki Nakagawa, Toshio Nishikimi,Koichiro Kuwahara 他
    • Organizer
      第77回日本循環器学会学術総会
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Year and Date
      20130315-17
  • [Presentation] 左室リモデリング進行及び催不整脈性抑制におけるレニン阻害の有用性の検討2012

    • Author(s)
      山田 千夏 桑原 宏一郎 中川 靖章 他
    • Organizer
      第16回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      20121100
  • [Presentation] Direct ReninInhibitor Strongly Prevents VentricularArrhythmogenic Remodeling and SuddenCardiac Death in Mice with DilatedCardiomyopathy2012

    • Author(s)
      Chinatsu Yamada, KoichiroKuwahara, Yasuaki Nakagawa他
    • Organizer
      2012 年米国心臓病学会議(AHA 2012)
    • Place of Presentation
      Los angeles, U.S.A
    • Year and Date
      20121100
  • [Presentation] N-Type Ca2+ Channel Blockade PreventsSudden Death in Mice with Heart Failure2012

    • Author(s)
      Yuko Yamada, Koichiro Kuwahara, HideyukiKinoshita, Yoshihiro Kuwabara, YasuakiNakagawa,他
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会
    • Place of Presentation
      福岡
    • Year and Date
      20121026-27
  • [Presentation] Direct renin inhibitor prevents ventricularremodeling and sudden arrhythmic death in micewith dilated cardiomyopathy2012

    • Author(s)
      C. Yamada, K.Kuwahara, T. Minami, Y. Kuwabara, K. Nakao,H. Kinoshita, S. Usami, Y. Nakagawa
    • Organizer
      2012 年欧州心臓学会議 (ESC2012)
    • Place of Presentation
      Munich, Germany
    • Year and Date
      20120800
  • [Presentation] Reciprocal expression of MRTF-A andmyocardin mediated by miR-1 is crucial forphenotypic modulation of vascular smoothmuscle cells2012

    • Author(s)
      Takeya Minami, KoichiroKuwahara, Yasuaki Nakagawa, 他
    • Organizer
      Arteriosclerosis, Thrombosis and VascularBiologyScientific Session 2012(ATVB 2012)
    • Place of Presentation
      Chicago
    • Year and Date
      20120418-20
  • [Presentation] 血管リモデリングにおける新規治療標的としてのRho依存性転写共役因子MRTF-Aの意義2012

    • Author(s)
      南 丈也・桑原宏一郎・中川靖章他
    • Organizer
      第49回日本臨床分子医学会
    • Place of Presentation
      京都
    • Year and Date
      20120413-14
  • [Presentation] Japan Increased HCN channels in failinghearts possibly contribute to ventriculararrhythmias2012

    • Author(s)
      Yoshihiro Kuwabara, KoichiroKuwahara, Makoto Takano, Hideyuki Kinoshita,Yasuaki Nakagawa他
    • Organizer
      The76th Annual Scientific Meeting of TheJapanese CirculationSociety
    • Place of Presentation
      Fukuoka International Congress Center, Fukuoka
    • Year and Date
      20120316-18
  • [Presentation] miR‐1を介したRho依存性転写共役因子MRTF‐A発現制御の血管リモデリングにおける意義2012

    • Author(s)
      南 丈也・桑原宏一郎・中川靖章他
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-04-23
  • [Presentation] Inhibition ofHCN overexpression in failing heart of dilatedcardiomyopathy mouse model by ivabradineprevents sudden arrhythmic death2011

    • Author(s)
      YoshihiroKuwabara, Koichiro Kuwahara, HideyukiKinoshita, Makoto Takano, Yasuaki Nakagawa,他
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Orlando, USA
    • Year and Date
      20111112-16
  • [Presentation] N-type Ca2+channel blockade prevents sudden arrhythmicdeath in ice with heart failure2011

    • Author(s)
      Yuko Yamada,Koichiro Kuwahara, Yasuaki Nakagawa, 他
    • Organizer
      4th Asia Pacific Heart Rhythm SocietyScientific Session (APHRS2011)
    • Place of Presentation
      Fukuoka
    • Year and Date
      20110920-22
  • [Presentation] N-Type Ca2+ ChannelBlockade Prevents Sudden Death in Mice withHeart Failure2011

    • Author(s)
      山田優子、桑原宏一郎、中川靖章、他
    • Organizer
      第28回日本心電学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20110918-22
  • [Presentation] HCN channel inhibition with ivabradine preventssudden arrhythmic death in a mouse model ofdilated cardiomyopathy2011

    • Author(s)
      Yoshihiro Kuwabara1,Koichiro Kuwahara, Hideyuki Kinoshita,Yasuaki Nakagawa他
    • Organizer
      European Society of Cardiology Congress2011
    • Place of Presentation
      Paris, France
    • Year and Date
      20110827-31
  • [Presentation] N-type Ca2+ channel blockade prevents suddendeath in mice with heart failure2011

    • Author(s)
      Yuko Yamada, Koichiro Kuwahara, Hideyukikinoshita, Yoshihiro Kuwabara, YasuakiNakagawa他
    • Organizer
      Basic Cardiovascular Sciences 2010 ScientificSessions
    • Place of Presentation
      New Orleans, LO, USA
    • Year and Date
      20110718-21
  • [Presentation] 「代謝制御からみた心筋障害・心不全の病態解明 ~基礎から臨床へ~」Implication ofTranscriptional Network RegulatingMitochondrial Function in Heart Failure2011

    • Author(s)
      Yasuaki Nakagawa
    • Organizer
      The75th Annual Scientific Meeting of TheJapanese Circulation Society March 18-19 2011
    • Place of Presentation
      Pacifico Yokohama, Yokohama Japan
    • Year and Date
      20110318-19
  • [Presentation] Rho 依存性SRF 共役転写因子MRTF-Aは血管リモデリングを制御する2011

    • Author(s)
      南 丈也・桑原宏一郎・中川靖章 他
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-23
  • [Presentation] Rho 依存性転写共役因子MRTF-Aによる血管リモデリング制御2011

    • Author(s)
      南 丈也・桑原宏一郎・中川靖章 他
    • Organizer
      第40回心脈管作動物質学会
    • Place of Presentation
      高松
    • Year and Date
      2011-02-04
  • [Presentation] Blockade of TRPC6 is a novel therapeuticapproach against pathological cardiachypertrophy2010

    • Author(s)
      Hideyuki Kinoshita, KoichiroKuwahara, Yasuaki Nakagawa,他
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20101113-17
  • [Presentation] Rho依存性転写共役因子myocardin-related transcription factor-Aの心肥大シグナルにおける役割2010

    • Author(s)
      桑原宏一郎、中川靖章 他
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      20101015-17
  • [Presentation] Blockade of TRPC6 is anovel therapeutic approach against pathologicalcardiac remodeling2010

    • Author(s)
      Hideyuki Kinoshita,Koichiro Kuwahara, Yasuaki Nakagawa他
    • Organizer
      第14回日本心不全学会 学術集会
    • Place of Presentation
      東京
    • Year and Date
      20101007-09
  • [Presentation]2010

    • Organizer
      20th European Meeting of Hypertension
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      20100618-21
  • [Presentation] TRPC6 is a novel therapeutic targetagainst pathological cardiac remodeling2010

    • Author(s)
      Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
    • Organizer
      0th World Congress of the InternationalSociety of Heart Research
    • Place of Presentation
      Kyoto
    • Year and Date
      20100513-16
  • [Presentation] 「新規心肥大治療法としてのTRPC阻害の効果」2010

    • Author(s)
      桑原宏一郎、中川靖章 他
    • Organizer
      第47回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20100409-10
  • [Presentation] Natriuretic Peptides-Guanylyl Cyclase-ASignaling Pathway Inhibits TRPC6-MediatedPro-Hypertrophic Signaling in the Hearts2010

    • Author(s)
      Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa 他
    • Organizer
      14th Annual Scientific Session of the Society ofCardiovacular Endocrinology and Metabolism
    • Place of Presentation
      Nara
    • Year and Date
      20100331-0401
  • [Presentation] 造影CTで偶発的に発見された右総頸動脈内血栓症の一例2010

    • Author(s)
      柴田純子、中川靖章、桑原宏一郎、 他
    • Organizer
      第110回日本循環器学会近畿地方会
    • Place of Presentation
      京都
    • Year and Date
      2010-11-27
  • [Presentation] バセドウ病を合併した滲出性収縮性心膜炎の1例2010

    • Author(s)
      山田千夏,桑原宏一郎,中川靖章,他
    • Organizer
      第192回日本内科学会近畿地方会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2010-09-11
  • [Presentation] 甲状腺機能低下を契機に心不全が増悪し多臓器不全に至った放射線治療後収縮性心膜炎の一例2010

    • Author(s)
      西尾直子、桑原宏一郎、中川靖章 他
    • Organizer
      第109回日本循環器学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2010-06-05
  • [Presentation] ANP・BNP 遺伝子発現調節因子NRSFにより制御されるHCNチャネルの心不全モデルマウスにおける突然死発症への関与

    • Author(s)
      〓原佳宏,桑原宏一郎,中川靖章,他
    • Organizer
      第15回日本心血管内分泌学会
    • Place of Presentation
      大阪
    • Year and Date
      00001125-26
  • [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討

    • Author(s)
      山田優子、桑原宏一郎、中川靖章、他
    • Organizer
      第34回日本日本高血圧学会総会
    • Place of Presentation
      宇都宮、栃木
    • Year and Date
      00001020-22
  • [Presentation] T-type Ca2+ channel blockade improvedsurvival and arrhythmogenicity in the mousemodel of myocardial infarction

    • Author(s)
      Yoshihiro Kuwabara, Koichiro Kuwahara,Yasuaki Nakagawa 他
  • [Presentation] Essential role of p300 in maintainingmitochondrial gene expression and cell survivalin the postnatal heart

    • Author(s)
      Yasuaki Nakagawa
  • [Presentation] N-Type Ca2+ Channel Blocker is Effective toPrevent Sudden CardiacDeath in Mice with Heart Failure

    • Author(s)
      Yuko Yamada, Koichiro Kuwahara,YasuakiNakagawa他
  • [Presentation] Blockade of TRPC6 is a Novel TherapeuticApproach Against Pathological CardiacHypertrophy

    • Author(s)
      Hideyuki Kinoshita, KoichiroKuwahara Yasuaki Nakagawa他
  • [Presentation] TRPC Ion Channels as Potentially NovelTherapeutic Targets for The Treatment ofPulmonary Arterial Hypertension

    • Author(s)
      HideyukiKinoshita, Koichiro Kuwahara, , YasuakiNakagawa, 他
  • [Presentation] HCN channel inhibition with ivabradineprevents sudden arrhythmic death in a mousemodel of dilated cardiomyopathy.

    • Author(s)
      YoshihiroKuwabara, Koichiro Kuwahara, , YasuakiNakagawa , 他
  • [Presentation] 受容体活性化型Ca2+チャネルTRPC3/6阻害の病的心肥大抑制効果

    • Author(s)
      木下秀之、桑原宏一郎、清中茂樹、森泰生、西田基宏、黒瀬等、榮向路、李育浩、中川靖章、他
  • [Presentation] ANP・BNP遺伝子発現調節因子NRSFの機能阻害による心筋症モデルマウスにおける不整脈発症・突然死に対するHCNチャネル阻害の効果

    • Author(s)
      〓原佳宏,桑原宏一郎,中川靖章 他
  • [Presentation] 病的血管リモデリングでみられる血管平滑筋細胞形質転換におけるRho依存性転写共役因子MRTF-Aの意義

    • Author(s)
      」南 丈也・桑原宏一郎・中川靖章 他
  • [Presentation] BNP遺伝子発現調節領域におけるserumresponse factor 応答領域の新たなる同定とその心筋細胞肥大反応における意義

    • Author(s)
      桑原宏一郎・木下秀之・〓原佳宏・中川靖章・他
  • [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討

    • Author(s)
      山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章 他
  • [Presentation] MRTF-A, a rho-dependent co-activator of SRF,plays a critical role in vascular remodeling byregulating smooth muscle cell migration

    • Author(s)
      Takeya Minami, Koichiro Kuwahara,YasuakiNakagawa 他
  • [Presentation] 拡張型心筋症マウスにおけるN型Ca2+チャネル阻害による自律神経活性調節を介した不整脈突然死予防の有用性

    • Author(s)
      山田優子、桑原宏一郎、中川靖章、他
  • [Presentation] Reciprocal expression of MRTF-A andMyocardin is crucial for pathological vascularremodeling in mice

    • Author(s)
      Takeya Minami, KoichiroKuwahara, Yasuaki Nakagawa, 他
  • [Presentation] Translational Repressor NRSF plays anessential role in maintaining normal cardiacstructure and function after birth

    • Author(s)
      YoshihiroKuwabara, Koichiro Kuwahara, YasuakiNakagawa 他
  • [Presentation] Inhibition of REnin-angiotensin system stronglyprevents arrhythmogenic left ventricularremodeling and sudden cardiac death in micewith dilated cardiomyopathy

    • Author(s)
      Chinatsu Yamada,Koichiro Kuwahara, Yasuaki Nakagawa 他
  • [Presentation] NRSF maintains normal cardiac structure andfunction

    • Author(s)
      Koichiro Kuwahara, YasuakiNakagawa他
  • [Presentation] Inhibition of TRPC6 Channel Conributes to theAnti-hypertrophic Effects of NatriureticPeptides-Guanylyl Cyclase-A Signaling in theHeart

    • Author(s)
      Koichiro Kuwahara, Yasuaki Nakagawa他
  • [Presentation] Blockade of T-Type Ca2+ Channel PreventsSudden Death in Mice With Heart Failure

    • Author(s)
      Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
  • [Presentation] Effect of functional inhibition of p300 on themitochondrial function and cell survival in thepost-natal heart in mice

    • Author(s)
      Yasuaki Nakagawa
  • [Presentation] Inhibition of TRPC6 Channel Contributes to theAnti-hypertrophic Effects Exerted by NatriureticPeptides-Guanylyl Cyclase-A Signaling in theHeart

    • Author(s)
      Koichiro Kuwahara, Yasuaki Nakagawa他
  • [Presentation] Basic Cardiovascular Sciences 2010 ScientificSessions Jul 19-22,2010. Rancho Mirage, CA,USA Blockade of TRPC Channel PreventsPathological Cardiac Hypertrophy

    • Author(s)
      Hideyuki Kinoshita, Koichiro Kuwahara,Yasuaki Nakagawa他
  • [Presentation] T-type Ca2+ Channel Blockade ImprovedCardiac Autonomic Nervous System Imbalanceand Reduced Sudden Death in Mice Model of Chronic Heart Failure

    • Author(s)
      Hideyuki Kinoshita,Koichiro Kuwahara, Yasuaki Nakagawa他
    • Organizer
      European Society of Cardiology Congress2010Aug28-Sept.01. Stockholm, Sweden
  • [Presentation] MRTF-A, a Rho-dependent coactivator of SRF,plays a critical role in vascular remodeling

    • Author(s)
      Takeya Minami, Koichiro Kuwahara, YasuakiNakagawa,他
  • [Presentation] Blockade of TRPC6/3 is a Novel TherapeuticApproach for Preventing Pathological CardiacHypertrophy

    • Author(s)
      Hideyuki Kinoshita, KoichiroKuwahara, Yasuaki Nakagawa, 他
  • [Presentation] Inhibition of HCN overexpressed in failingheart of dilated cardiomyopathy mouse model byivabradine prevents sudden arrhythmic death

    • Author(s)
      Yoshihiro Kuwabara, Koichiro Kuwahara, ,Yasuaki Nakagawa, 他
  • [Presentation] N-Type Ca2+ Channel Blocker is Effective toPrevent Sudden Cardiac Death in Mice withHeart Failure

    • Author(s)
      Yuko Yamada, Koichiro Kuwahara, HideyukiKinoshita, Yoshihiro Kuwabara, YasuakiNakagawa, 他
  • [Presentation] Induction of Myocardin-Related TranscriptionFactor-A Contributes to the PhenotypicAlteration of Vascular Smooth Muscle Cells andPlays a Pivotal Role in Vascular Remodeling

    • Author(s)
      Takeya Minami, Koichiro Kuwahara, YasuakiNakagawa, 他
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~med2/jpn/research/cardio.html

URL: 

Published: 2014-08-29  

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