2012 Fiscal Year Final Research Report
Heart failure rescued by an anti-viral drug which inhibits cardiacadenylyl cyclasefor aging society
| Project/Area Number |
22590811
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Satoshi 鶴見大学, 歯学部, 教授 (60233475)
KUROTANI Reiko 山形大学, 大学院・理工学研究科, 助教 (00453043)
IWATSUBO Kosaku 横浜市立大学, 医学研究科, 客員准教授 (90363796)
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| Project Period (FY) |
2010 – 2012
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| Keywords | シグナル伝達 / 循環器・高血圧 / サイクリックAMP / 心不全 |
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| Research Abstract |
The aim of this study is to developa cardiac adenylyl cyclase inhibitor as a drug for the treatment of heart failure and arrhythmia. We have demonstrated that a pharmacological inhibitor of AC5,Vidarabine,and a newly developed and water-soluble vidarabine prodrugameliorates the development of heart failure and arrhythmia(H22-23). We also confirmed the effectiveness ofvidarabine on atrial fibrillation aftercardiac surgery in humans in Yokohama City University Hospital with thecollaboration of cardiac surgerygroup(H24).
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[Journal Article] Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight2012
Author(s)
Bai Y,Tsunematsu T, Jiao Q, Ohnuki Y, Mototani Y, Shiozawa K, Jin M, Cai W, Jin HL, Fujita T, Ichikawa Y, Suita K, Kurotani R, Yokoyama U, Sato M, Iwatsubo K, Ishikawa Y, Okumura S
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Journal Title
J Pharmacol Sci
Volume: 119
Pages: 381-189
Peer Reviewed
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[Journal Article] Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase2012
Author(s)
Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura S, Lai L, Gao S, Yan L, Zhao X, Park M, Qiu H, Okumura S, Iwatsubo M, Vatner SF, Vatner DE
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 302
Pages: H2622-H2628
Peer Reviewed
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[Presentation] Disruption of Epac1 decreases phosphorylation of phospholamban and protects the heart against stress2012
Author(s)
Satoshi Okumura, Meihua Jing, Yoshiki Ohnuki, Iyuki Namekata, Reiko Kurotani, Takayuki Fujita, Hui-Ling Jin, Wengian Cai, Yunzhe Bai, Kenji Suita, Takashi Tsunematsuet al
Organizer
American Heart Association Scientific Scission
Place of Presentation
Los Angeles, California, USA
Year and Date
2012-11-06
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