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2012 Fiscal Year Final Research Report

Evaluation of mechanisms by which caloric restriction regulates mitochondrial function

Research Project

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Project/Area Number 22590814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKeio University

Principal Investigator

SHINMURA Ken  慶應義塾大学, 医学部, 講師 (70206332)

Research Collaborator SUEMATSU Makoto  慶應義塾大学, 医学部, 教授 (00206385)
FUKUDA Keiichi  慶應義塾大学, 医学部, 教授 (20199227)
OTA Shigeo  日本医科大学, 医学研究科, 教授 (00125832)
TSUBOTA Kazuo  慶應義塾大学, 医学部, 教授 (40163878)
ADACHI Takeshi  防衛医科大学校, 医学教育部・医学科専門課程, 教授 (50231931)
SANO Motoaki  慶應義塾大学, 医学部, 准教授 (30265798)
KAMIMURA Naomi  日本医科大学, 医学研究科, 講師 (60283800)
Project Period (FY) 2010 – 2012
Keywordsカロリー制限 / 心筋虚血 / 心保護 / 電子伝達系 / 脱アセチル化 / ミトコンドリア / sirtuin / SIRT1
Research Abstract

Caloric restriction (CR) confers cardioprotection against ischemia/reperfusion injury. We speculated that CR primes mitochondria for stress-resistance by post-transcriptional modification of specific mitochondrial proteins. We found that deacetylation of

  • Research Products

    (10 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Effects of caloric restriction on cardiac oxidative stress and mitochondrial bioenergetics: potential role of cardiac sirtuin.2013

    • Author(s)
      Shinmura K
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2013 Pages: 528935

    • DOI

      Doi:10.1155/2013/528935.

    • Peer Reviewed
  • [Journal Article] Posttranslational modification of mitochondrial proteins by caloric restriction: Possible involvement of caloric restriction-induced cardioprotection.2013

    • Author(s)
      Shinmura K.
    • Journal Title

      Trends Cardiovasc Med

      Volume: 23(1) Pages: 18-25

    • DOI

      doi:10.1016/j.tcm.2012.08.006.

    • Peer Reviewed
  • [Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain.2011

    • Author(s)
      Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Alexander MW, Amo T, Ota S, Katsumata Y, Fukuda K, Ishiwata K, Suematsu M, Adachi T.
    • Journal Title

      Circ Res

      Volume: 109(4) Pages: 396-406

    • DOI

      Doi:10.1161/CIRCRESAHA.111.243097.

    • Peer Reviewed
  • [Presentation] Meet the Expert: カロリー制限による加齢関連循環器疾患治療戦略2013

    • Author(s)
      新村 健.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-16
  • [Presentation] Cardiac Sirt1 is essential for caloric restriction-induced cardioprotection against ischemia/reperfusion.2012

    • Author(s)
      Shinmura K, Yamamoto T, Tamaki K, Sano M, Fukuda K, Inaba T, Tsubota K.
    • Organizer
      Keystone Symposia: Aging and Diseases of Aging.
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2012-10-27
  • [Presentation] Symposium: Mitochondrial injury of heart and vessel disease. Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of electron transport chain.2012

    • Author(s)
      Shinmura K
    • Organizer
      Annual Meeting of the Korean Society of Cardiology 2012
    • Place of Presentation
      Busan, South Korea
    • Year and Date
      2012-04-20
  • [Presentation] トピックス: 心血管系のanti-aging. Mitochondria at the crossroad of metabolic stress and cardiovascular aging.2012

    • Author(s)
      新村 健
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-16
  • [Presentation] Posttranslational modification of mitochondrial proteins by sirtuin during caloric restriction.2012

    • Author(s)
      Shinmura K, Tamaki K, Sano M, Yamamoto T, Fukuda K, Tsubota K.
    • Organizer
      Keystone Symposia: Sirtuins in metabolism, aging and disease.
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2012-02-14
  • [Presentation] シンポジウム: カロリーリストリクションの応用による心血管疾患治療戦略2011

    • Author(s)
      新村 健
    • Organizer
      第11回日本坑加齢医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2011-05-27
  • [Book] Adipokines as novel biomarkers in aging and heart failure. (eds. Bodh I. Jugdutt) Aging and heart failure: Mechanisms and management.2013

    • Author(s)
      Shinmura K.
    • Publisher
      Springer, New York

URL: 

Published: 2014-08-29  

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