2012 Fiscal Year Final Research Report
Elucidation of the protective effect of PAI-1 in coronary microvascular wall and application to the new treatment of myocardial infarction
| Project/Area Number |
22590819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
KANEKO Takeaki 北海道大学, 大学院・医学研究科, 助教 (90455634)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Hiroyuki 北海道大学, 大学院・医学研究科, 教授 (70264017)
ISHIMORI Naoki 北海道大学, 病院, 助教 (70399848)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 循環器 / 分子生物学 / 動脈硬化 / 心筋梗塞 / 心破裂 / 心筋リモデリング |
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| Research Abstract |
PAI-1 protected the coronary vessel walls of the myocardial infarct area and stabilized the adhesion of vascular endothelial cells to the basement membrane and inhibited a cardiac rupture by inhibiting bleeding and the inflammatory cells infiltration to cardiac interstitium after MI, and it was found to inhibit cardiac remodeling after MI.An activation of plasminogen-plasmin system due to uPA activity which was suppressed by PAI-1 activity was associated with the mechanism of coronary microvascular collapse and cardiac rupture after myocardial infarction. It was suggested that an activation of MMPs (MMP-9, MMP-2) degraded an extracellular matrix and developed cardiac rupture.
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