2012 Fiscal Year Final Research Report
Transcriptional Regulation by Mrf-2/ARID5B in Cardiovascular and Metabolic diseases
| Project/Area Number |
22590824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MANABE Ichiro 東京大学, 医学部附属病院, 講師 (70359628)
IMAI Yasushi 東京大学, 医学部附属病院, 特任講師 (20359631)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 転写因子 / アディポネクチン / 血管新生 / 線維化 |
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| Research Abstract |
We hypothesized that the transcription factor ARID5B has a role in responding to the stress from the outside. Our research revealed that ARID5B was contributed to the expression of adiponectin, angiogenesis, and suppression of cardiac fibrosis by at least two different ways.
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[Presentation] ARID5Bヘテロ欠損マウスは高脂肪食下で肥満が抑制されインスリン抵抗性は改善した2012
Author(s)
大関敦子,渡辺昌文,眞鍋一郎,王国琴,今井靖,山内敏正,原一雄,渡邉綾,河原崎秀一,前村浩二,門脇孝,山崎力,永井良三
Organizer
第33回日本肥満学会大会
Place of Presentation
京都
Year and Date
2012-10-11
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