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2012 Fiscal Year Final Research Report

The regulation of endothelial migration and angiogenesis by transcriptiona l coact I vator PGC-1aIpha

Research Project

  • PDF
Project/Area Number 22590825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SAWADA Naoki  東京医科歯科大学, 歯と骨のGCOE拠点, GCOE拠点形成特任教員 (40343751)

Co-Investigator(Renkei-kenkyūsha) SATA Masataka  徳島大学, ヘルスバイオサイエンス研究, 教授 (80345214)
Research Collaborator ZOLT Arany  Beth Israel Deaconess Medical Center, Harvard Medical School, Associate Professor of Medicine
Project Period (FY) 2010 – 2012
Keywords分子血管病態学
Research Abstract

Critical limb ischemia, the leading cause oflimb amputation, affects 10-15%ofdiabetic population, thus calling for critical needs to develop effective therapeutic means. The high prevalence oflimb ischemia in diabetes is in significant part caused by the inability of diabetics to elaborate new blood vessels (the process called angiogenesis) to resume blood supply in ischemic tissues. However, the underlying mechanism fbr this has been largely undefined. In the present study, we demonstrated that diabetes increases the abundance oftranscriptional co-activator PGC-1αin endothelial cells, which then renders endothelial cells unresponsive to angiogenic factors, and causes diminished angiogenic capacity in diabetes.

  • Research Products

    (10 results)

All 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis2013

    • Author(s)
      Sawada N, Liao JK
    • Journal Title

      Antioxid Redox Signal

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Glucose-independent persistence of PAl-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium; lmplication in metabolic memory2013

    • Author(s)
      Takizawa F, Mizutani S, Ogawa Y Sawada N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433(1) Pages: 66-72

    • Peer Reviewed
  • [Journal Article] Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages2010

    • Author(s)
      Yamashiro K, Sasano T, Tbjo K, Namekata l, Kurokawa J, Sawada N, Suganami T, Kamei Y Tanaka H,Tajima N, Utsunomiya K, Ogawa Y Furukawa T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 398(2) Pages: 284-289

    • Peer Reviewed
  • [Journal Article] Endothelial PGC-1α mediates vascular dysfunction in diabetes

    • Author(s)
      Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang K-T, Bischoff J, Kalwa H, Sartoretto J, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z
    • Journal Title

      Cell Metab

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] Endothelial PGC-1alpha mediates vascular dysfunction in diabetes2013

    • Author(s)
      Naoki Sawada, Aihua Jiang, Fumihiko Takizawa, Kevin Croce, Andre Manika, Yevgenia Tesmenitsky, Kyu Tae Kang, Joyce Bischoff, Hermann Kalwa, Thomas Michel,Yasutomi Kamei, Laura E. Benjamin, Masataka Sata, Yoshihiro Ogawa, Zolt Arany
    • Organizer
      The American Society for Clinical lnvestigation/Association of American Physicians Joint Meeting
    • Place of Presentation
      Chicago, lllinois, USA
    • Year and Date
      20130426-28
  • [Presentation] Endothelial PGC-1alpha mediates vascular dysfunction in diabetes2013

    • Author(s)
      Naoki Sawada, Aihua Jiang, Fumihiko Takizawa, Kevin Croce, Andre Manika, Yevgenia Tesmenitsky, Kyu Tae Kang, Joyce Bischoff, Hermann Kalwa, Thomas Michel, Yasutomi Kamei, Laura E. Benjamin, Masataka Sata, Shuki Mizutani, Yoshihiro Ogawa, Zolt Arany
    • Organizer
      Gordon Research Conference, Vascular Cell Biology
    • Place of Presentation
      Ventura, California, USA
    • Year and Date
      20130127-0201
  • [Presentation] Endothelial PGC-1alpha mediates vascular dysfunction in diabetes2013

    • Author(s)
      Fumihiko Takizawa, Naoki Sawada, Aihua Jiang, Kevin Croce, Andre Manika, Yevgenia Tesmenitsky, Kyu Tae Kang, Joyce Bischoff, Hermann Kalwa, Thomas Michel, Laura E. Benjamin, Masataka Sata, Zolt Arany
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2013-03-16
  • [Presentation] Racl GTPase is a critical mediator of endothelium-derived neurotrophic activity2012

    • Author(s)
      Naoki Sawada, Ybshihiro Ogawa, James K. Liao
    • Organizer
      Neuro-Vascular Wiring Sym posium 2012
    • Place of Presentation
      Nara, Japan
    • Year and Date
      20121112-13
  • [Presentation] Endothelial PGC-1alpha mediates vascular dysfunction in diabetes2012

    • Author(s)
      Naoki Sawada, Aihua Jiang, Fumihiko Takizawa, Kevin Croce, Andre Manika, Yevgenia Tesmenitsky, Kyu Tae Kang, Joyce Bischoff, Hermann Kalwa, Thomas Michel, Yasutomi Kamei, Laura E. Benjamin, Masataka Sata, Shuki Mizutani, Yoshihiro Ogawa, Zolt Arany
    • Organizer
      ATVB Early Career Investigator Award competition, American Heart Association Scientific Sessions 2012
    • Place of Presentation
      Los Angeles, California, USA
    • Year and Date
      20121103-07
  • [Presentation] Endothelial PGC-1alpha is highly responsive to metabolic stress and serves as a key determinant of angiogenic response. Symposium' Young Scientist lnitiative Program2011

    • Author(s)
      Naoki Sawada, Aihua Jiang, Fumihiko Takizawa, Kevin Croce, Andre Manika, Yevgenia Tesmenitsky, Kyu Tae Kang, Joyce Bischoff, Hermann Kalwa, Thomas Michel, Yasutomi Kamei, Laura E. Benjamin, Masataka Sata, Shuki Mizutani, Yoshihiro Ogawa, Zolt Arany
    • Organizer
      The 19th Scientific session. Japanese Vascular Biology and Medical Organization
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-12-09

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Published: 2014-08-29  

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