Identification of MicroRNAs involved in formation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590827
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: SAKATA Yasuhiko 大阪大学, 大学院・医学系研究科, 助教 (90379206)
• Co-Investigator(Kenkyū-buntansha): 中谷 大作 大阪大学, 医学系研究科, 研究員 (60444535) ; 砂 真一郎 大阪大学, 歯学研究科, 助教 (40573085)
• Project Period (FY): 2010 – 2012
• Keywords: 分子血管病態学

Research Abstract

We tried to Identify microRNAs involved in f ormation of foam cells that are associated with atherosclerosis-related gene lymphotoxin-alpha (LTA). However, we found that LTA was unlikely involved in foam cell formation. Thus, we changed our plan and identified microRNAs that are associated with cardiac death in patients who survived acute myocardial infarction, a major cause of death as a result of atherosclerotic diseases.

Research Products

• [Journal Article] on Behalf of The Osaka Acute Coronary Insufficiency Study (OACIS) Group Incidence Predictors, and Subsequent Mortality Risk of Recurrent Myocardial Infarction in Patients following Discharge for Acute Myocardial Infarction. (2013)
  • Author(s): Nakatani D, Sakata Y, Suna S, Usami M, Matsumoto S, Shimizu M, Sumitsuji S, Kawano S, Ueda Y, Hamasaki T, Sato H, Nanto S, Hori M, Komuro I
  • Journal Title: Circ J. Volume: 77 Pages: 439-446
• [Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction. (2012)
  • Author(s): Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Nanto S, Hamasaki T, Hori M, Komuro I.
  • Journal Title: Biochem Biophys Res Commun Volume: 427 Pages: 280-4
• [Presentation] Circulating MicroRNAs as Therepeutic Targets for Cardiac Remodeling and Heart Failure in Patients after Acute Myocardial Infarction. (2013)
  • Author(s): Sen Matsumoto, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Masahiko Hara, Yukio Kawahara, Toru Oka, Seiji Takashima, Tatsuya Sasaki, Hiroshi Sato, Shinsuke Nanto, Issei Komuro
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-15
• [Presentation] The association of circulating microRNAs with prognosis of patients after acute myocardial infarction (2011)
  • Author(s): 松本 專、坂田泰彦、中谷大作、砂真一郎、宇佐美雅也、原正彦、南都伸介、小 室 一 成
  • Organizer: 第28回国際心臓研究会
  • Place of Presentation: 日本部会(東京).
  • Year and Date: 2011-12-03
• [Presentation] on behalf of Osaka Acute Coronary Insufficiency Study (OACIS) Group. Cardiovascular Events Associated with Lymphotoxin Alpha and its Polymorphism After the Onset of Myocardial Infarction (2011)
  • Author(s): Shinichiro Suna, Yasuhiko Sakata, Daisaku Nakatani, Masaya Usamai, Sen Matsumoto, Keiji Okuda, Kouichi Ozaki, Seiji Takashima, Tetsuo Minamino, Toshihiro Tanaka, Hiroshi Sato, Masatsugu Hori, Shinsuke Nanto, Issei Komuro
  • Organizer: Annual Congress of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-11-16
• [Presentation] on behalf of Osaka Acute Coronary Insufficiency Study (OACIS) Group. Incidence, Predictors, and Long-Term Mortality of Recurrent Myocardial Infarction in Patients following Discharge for Acute Myocardial Infarction (2011)
  • Author(s): Daisaku Nakatani, Yasuhiko Sakata, Shinichiro Suna, Masaya Usamai, Sen Matsumoto, Toshimitsu Hamasaki, Hiroshi Sato, Masatsugu Hori, Shinsuke Nanto, Issei Komuro
  • Organizer: Annual Congress of American Heart Association
  • Place of Presentation: Orlando, USA.
  • Year and Date: 2011-11-16