2012 Fiscal Year Final Research Report
A New Approach to Aortic Aneurysm Research
| Project/Area Number |
22590829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
YOSHIZUMI Masao 広島大学, 医歯薬保健学研究院, 教授 (20282626)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Mari 広島大学, 大学院・医歯薬保健学研究院, 講師 (30359898)
TSUJI Toshio 広島大学, 大学院・工学研究院, 教授 (90179995)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大動脈瘤 / 循環器病学 / 血管粘弾性 / 血管超音波 / 動脈硬化 |
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| Research Abstract |
Although clinical studies in patients showed a positive association between serum osteoprotegerin (OPG) levels and vasculardiseases, there are conflicting reports regarding OPG levels in human aortic aneurysm tissue. Accordingly, we aimed to investigate the role of OPG in aortic aneurysm formation. Our results suggest that OPG may have a protective role against aneurysm formation in mice probably through anti-inflammatory or anti-apoptotic effect. As a new approach to arterial diseases, we have developed a consortium of biomedical engineering, and developed a new apparatus for evaluating vascular endothelial function.
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