The role of cholinergic anti-inflammatory pathway in the development of cardiovascular diseases.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: ICHIKI Tosihiro 九州大学, 大学院・医学研究院, 教授 (80311843)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Kotaro 九州大学, 大学院・医学研究院, 助教 (50467908)
• Project Period (FY): 2010 – 2012
• Keywords: コリン作動性抗炎症経路 / コリンエステラーゼ阻害薬 / 自然免疫 / 動脈硬化 / 酸化ストレス

Research Abstract

Activation of cholinergic anti-inflammatory pathway by acetylcholine esterase inhibitors attenuated atherogenesis in apolipoprotein E-deficient mice fed a high-fat diet and blood flow recovery in a hindlimb ischemia model in mice. These effects seemed to be mediated by suppression of cytokine expression. Acetylcholine esterase inhibitors may be a novel strategy for the treatment of cardiovascular diseases.

Research Products

• [Journal Article] Acetylcholinesterase Inhibitors Attenuate Angiogenesis (2012)
  • Author(s): Miyazaki R, Ichiki T, Hashimoto T, Ikeda J, Kamiharaguchi A, Narabayashi E, Matsuura H, Takeda K, Sunagawa K
  • Journal Title: Clin Sci (Lond) Volume: 123 Pages: 241-249
  • Peer Reviewed
• [Journal Article] Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoproteinE-knockout mice (2010)
  • Author(s): Inanaga K, Ichiki T, Miyazaki R, Takeda K, Hashimoto T, Matsuura H, Sunagawa K
  • Journal Title: Atherosclerosis Volume: 213 Pages: 52-58
  • Peer Reviewed
• [Presentation] Role of Acetylcholinesterase in Atherogenesis and Angiogenesis (2012)
  • Author(s): Toshihiro Ichiki, Kenji Sunagawa
  • Organizer: 第76回日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-18
• [Presentation] アルツハイマー病治療薬のドネペジルは血管新生と腫瘍形成を抑制する (2011)
  • Author(s): 市来俊弘、砂川賢二
  • Organizer: 第59回日本心臓病学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 20110923-25
• [Presentation] Pharmacological activation of the cholinergic anti-inflammatory pathway ameliorates atherosclerosis in apolioprotein E-deficient mice (2011)
  • Author(s): Toru Hashimoto, Toshihiro Ichiki
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 札幌市
  • Year and Date: 20110715-16
• [Presentation] Anti-atherogenic and anti-angiogenic effects of donepezil: a drug for Alzheimer's disease (2011)
  • Author(s): Ichiki T, Sunagawa K
  • Organizer: 60th Annual Scientific Sessions of American College of Cardiology
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 20110402-05
• [Presentation] Anti-atherogenic and anti-angiogenic effect of cholinesterase inhibitors (2010)
  • Author(s): Ichiki T, Inanaga K Miyazaki R, Sunagawa K
  • Organizer: 19th Intrenational Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20100923-26
• [Presentation] Biology 2010 Scientific Sessions (2010)
  • Author(s): Arteriosclerosis, Thrombosis and Vascula
  • Organizer: Cholinesterase inhibitor attenuates atherogenesis in apolipoprotein E knockout mice through anti-oxidant and anti-inflammatory effects
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 20100408-10
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/3_shinkekkan/