2012 Fiscal Year Final Research Report
Risk factors for inflammatory obstructive pulmonary diseases: a prospective cohort study.
| Project/Area Number |
22590834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIZAWA Nobuyuki 筑波大学, 医学医療系, 教授 (00301896)
NOGUCHI Emiko 筑波大学, 医学医療系, 准教授 (40344882)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMARI Mayumi 独立行政法人理化学研究所, ゲノム医科学研究センター, チームリーダー (00217184)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 喘息 / 慢性閉塞性肺疾患 / 遺伝子多型 / 前向き研究 |
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| Research Abstract |
Inflammatory obstructive pulmonary diseases such as asthma and COPD are heterogeneous diseases modified by interaction between environmental andintrinsic host factors. This study demonstrated that airflow obstruction is associated withsingle-nucleotide polymorphisms (SNPs) of the TSLP gene, and that annual decline of FEV1 is associated with that of the Nrf2 gene. It has been revealed that the persons with the new onset of COPD have significantly lower FEV1/FVC than the normal controls at thetime point of the study entry. Furthermore, the persons with the new onset of asthma have significantly larger annual decline of FEV1 than the normal controls at the study entry, suggesting that adult-onset asthma patients have rapid decline of FEV1 even before affection of the disease.
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[Journal Article] A distinct sensitization pattern associated with asthma and the thymic stromal lymphopoietin (TSLP) genotype2013
Author(s)
Iijima H, Kaneko Y, Yamada H, Yatagai Y, Masuko H, Sakamoto T, Nai t o T, Hirota T, Tamari M, Konno S, Nishimura M, Noguchi E, Hizawa N.
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Journal Title
Allergol Int.
Volume: 62(1)
Pages: 123-30
DOI
Peer Reviewed
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[Journal Article] Asthma phenotypes in Japanese adults - their associations with the CCL5 and ADRB2 genotypes2013
Author(s)
Kaneko Y, Masuko H, Sakamoto T, Iijima H, Naito T, Yatagai Y, Yamada H, Konno S, Nishimura M, Noguchi E, Hizawa N
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Journal Title
Allergol Int
Volume: 62(1)
Pages: 113-21
DOI
Peer Reviewed
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[Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population2012
Author(s)
Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T
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Journal Title
Nat Genet
Volume: 44(11)
Pages: 1222-6
Peer Reviewed
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[Journal Article] Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies2011
Author(s)
Hirota T, Saeki H, Tomita K, Tanaka S, Ebe K, Sakashita M, Yamada T, Fujieda S, Miyatake A, Doi S, Enomoto T, Hizawa N, Sakamoto T, Masuko H, Sasaki T, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Noguchi E, Kamatani N, Nakamura Y, Kubo M, Tamari
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Journal Title
PLoS One
Volume: 6(11)
Pages: e26987
DOI
Peer Reviewed
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[Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011
Author(s)
Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S,Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N
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Journal Title
PLoS Genet
Volume: 7(7)
Pages: e1002170
DOI
Peer Reviewed
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[Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population2011
Author(s)
Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Doi S, Fujita K, Miyatake A, Enomoto T, Miyagawa T, Adachi M, Tanaka H, Niimi A, Matsumoto H, Ito I, Masuko H, Sakamoto T, Hizawa N, Taniguchi M, Lima JJ, Irvin CG, Peters SP, Himes BE, Litonjua AA, Ta
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Journal Title
Nat Genet
Volume: 43(9)
Pages: 893-6
DOI
Peer Reviewed
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[Journal Article] Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes2011
Author(s)
Masuko H, Sakamoto T, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T, Tamari M, Hizawa N
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Journal Title
Int J Chron Obstruct Pulmon Dis
Volume: 6
Pages: 181-9
DOI
Peer Reviewed
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[Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011
Author(s)
Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias
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Journal Title
Am JRespir Cell Mol Biol
Volume: 44(6)
Pages: 787-93
DOI
Peer Reviewed
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