2012 Fiscal Year Final Research Report
Development of the treatment of mucus overproduction in COPD using an animal model of elastase-induced goblet cell metaplasia
| Project/Area Number |
22590844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KONDO Mitsuko 東京女子医科大学, 医学部, 講師 (50178430)
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| Project Period (FY) |
2010 – 2012
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| Keywords | エラスターゼ / 杯細胞化生 / ムスカリン受容体 / チオトロピウム / COPD / MUC5AC |
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| Research Abstract |
Airway occlusion by mucus in COPD is associated with a poor prognosis. Repeated-elastase aspiration induced marked goblet cell metaplasia in mice. The goblet cell metaplasia, increase in inflammatory cells and chemokine levels in BALF, M3receptor expression, MUC5AC production in vitro were inhibited by tiotropium. This result suggests that tiotropium may be useful for the treatment of mucus overproduction by anti-inflammatory action and a direct action on epithelial cells
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