2012 Fiscal Year Final Research Report
Basic study for development of new therapy on ALI/ARDS by targeting flavonoid-induced HO-1
| Project/Area Number |
22590856
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
KAWABE Tsutomu 名古屋大学, 医学系研究科(保健), 教授 (20378219)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Miyoko 名古屋大学, 医学系研究科(保健), 助教 (10509665)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | フラボノイド / heme oxygenase-1 / 急性肺損傷/急性呼吸促迫症候群(ALI/ARDS) |
|---|
| Research Abstract |
Tissue destruction by activated neutrophils invading in the lungs is important in the pathogenesis of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Pulmonary fibrosis or restoration of the normal pulmonary architecture occurs after ALI/ARDS, and there is no specific therapy available yet in preventing and/or treating ALI/ARDS. In this study, we showed that quercetin, one of the flavonoids, suppressed lung damage via Nrf2-HO-1 pathway and the possibilitiesof using flavonoids to develop drug therapy for ALI/ARDS
|
-
[Journal Article] Anaqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans2013
Author(s)
Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y
-
Journal Title
Respirology
Volume: 18(2)
Pages: 340-7
DOI
Peer Reviewed
-
[Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury.2012
Author(s)
Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y.
-
Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 303(1)
Pages: L43-53
DOI
Peer Reviewed
-
-
[Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells2012
Author(s)
Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.
-
Journal Title
Mol Carcinog
Volume: 51(5)
Pages: 400-10
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
