Exploration of new therapy and diagnosis in lymph metastasis of lung cancer based on theprofile of lymphangiogenic-related genes expression

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Fujita Health University (2011-2012); Nagoya University (2010)
• Principal Investigator: IMAIZUMI Kazuyoshi 藤田保健衛生大学, 医学部, 教授 (50362257)
• Co-Investigator(Kenkyū-buntansha): SATO Mitsuo 名古屋大学, 医学系研究科, 講師 (70467281)
• Project Period (FY): 2010 – 2012
• Keywords: 呼吸器病学

Research Abstract

Based on our recognition for the importance of tumor microenvironment(TM), TM induces acquisition of malignant phenotype such as epithelial-mesenchymal transition (EMT), resulting in metastasis into lymph nodes. In this study, persistent tissue hypoxia might be involved in tumor tissue in an in vivo orthotopic intrapulmonary implantation model. Persistent hypoxia also induced the stabilized HIF1α expression in lung cancer cells. Transduction of HIF1α into lung cancers with the Doxycycline inducible gene expression system caused de novo VEGF-A expression. Taken together with the evidence of increasing VEGF receptor expression lymphatic endothelial cells in sentinel lymph nodes, hypoxia as TM in lung cancers might be a therapeutic target for the metastasis into lymph nodes and lymphangiogenesis.

Research Products

• [Journal Article] Endobronchial ultrasound transbronchial needle aspiration in older people (2013)
  • Author(s): Okachi S, Imai N, Imaizumi K, Hase T,Shindo Y, Sakamoto K, Aso H, Wakahara K,Hashimoto I, Ito S, Hashimoto N, Sato M,Kondo M, Hasegawa Y.
  • Journal Title: Geriatr Gerontol Int
  • DOI: doi:10.1111/ggi.12043
  • Peer Reviewed
• [Journal Article] Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice (2013)
  • Author(s): Ohno T, Okamoto M, Hara T, Hashimoto N,Imaizumi K, Matsushima M, Nishimura M,Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: Immunogenetics Volume: 65(1) Pages: 17-24
  • Peer Reviewed
• [Journal Article] An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (2013)
  • Author(s): Hashimoto I, Imaizumi K, Hashimoto N,Furukawa H, Noda Y, Kawabe T, Honda T,Ogawa T, Matsuo M, Imai N, Ito S, Sato M,Kondo M, Shimokata K, Hasegawa Y.
  • Journal Title: Respirology Volume: 18(2) Pages: 340-347
  • Peer Reviewed
• [Journal Article] Febrile complications after endobronchial ultrasound-guided transbronchial needle aspiration for intra-pulmonary mass lesions of lung cancer-a series of 3 cases. (2012)
  • Author(s): Oguri T, Imai N, Imaizumi K, Elshazley M,Hashimoto I, Hashimoto N, Hasegawa Y
  • Journal Title: Respir Investig Volume: 50(4) Pages: 162-165
  • Peer Reviewed
• [Journal Article] Non-Genomic Effects of Fluticasone Propionate and Budesonide on Human Airway Anion Secretion (2012)
  • Author(s): Mizutani T, Morise M, Ito Y, Hibino Y,Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 47(5) Pages: 645-51
  • Peer Reviewed
• [Journal Article] Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. (2012)
  • Author(s): Sakamoto K, Hashimoto N, Kondoh Y,Imaizumi K, Aoyama D, Kohnoh T,Kusunose M, Kimura M, Kawabe T,Taniguchi H, Hasegawa Y
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 303(1) Pages: L43-53
  • Peer Reviewed
• [Journal Article] Interstitial pneumonia and nodular regenerative hyperplasia of the liver as initial manifestations of polyarteritis nodosa (2012)
  • Author(s): Tanaka I, Imaizumi K, Hashimoto I, Asai N,Yokoi T, Matsuno T, Hasegawa Y
  • Journal Title: Intern Med. Volume: 51(6) Pages: 635-8
  • Peer Reviewed
• [Journal Article] Inspiratory capacity as a preoperative assessment of patients undergoing thoracicsurgery (2012)
  • Author(s): Matsuo M, Hashimoto N, Usami N,Imaizumi K, Wakai K, Kawabe T, Yokoi K,Hasegawa Y
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 14(5) Pages: 560-4
  • Peer Reviewed
• [Journal Article] Three Cases of Bronchial Asthma Preceding IgG4-Related Autoimmune Pancreatitis (2012)
  • Author(s): Ito S, Ko SB, Morioka M, Imaizumi K,Kondo M, Mizuno N, Hasegawa Y
  • Journal Title: Allergol Int Volume: 61(1) Pages: 171-174
  • Peer Reviewed
• [Journal Article] Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells (2012)
  • Author(s): Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: Biochem Biophys Res Commun. Volume: 417(1) Pages: 169-174
  • Peer Reviewed
• [Journal Article] Acute exacerbation of IPF following diagnostic bronchoalveolar lavage procedures. (2012)
  • Author(s): Sakamoto K, Taniguchi H, Kondoh Y, Wakai K, Kimura T, Kataoka K, Hashimoto N,Nishiyama O, Hasegawa Y
  • Journal Title: Respir Med Volume: 106(3) Pages: 436-42
  • Peer Reviewed
• [Journal Article] Mesenchymal Stem Cells Stably Transduced with a Dominant-Negative Inhibitor of CCL2 Greatly Attenuate Bleomycin-Induced Lung Damage. (2011)
  • Author(s): Saito S, Nakayama T, Hashimoto N, MiyataY, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T
  • Journal Title: Am J Pathol Volume: 179(3) Pages: 1088-94
  • Peer Reviewed
• [Journal Article] Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells. (2011)
  • Author(s): Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M,Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y
  • Journal Title: Mol Carcinog. Volume: 51(5) Pages: 400-410
  • Peer Reviewed
• [Journal Article] Capsaicinoids regulate airway anion transporters through Rho kinase- and cAMP-dependent mechanisms (2011)
  • Author(s): Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, and Hasegawa Y
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45(4) Pages: 684-91
  • Peer Reviewed
• [Journal Article] Attenuation of TGF-ss-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. (2011)
  • Author(s): Nakamura T, Matsushima M, Hayashi Y,Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T
  • Journal Title: Am J Respir Cell Mol Biol Volume: 44(5) Pages: 614-20
  • Peer Reviewed