2012 Fiscal Year Final Research Report
Analysis of the roles of mDia in refractory pulmonary diseases
| Project/Area Number |
22590862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
OGA Toru 京都大学, 医学研究科, 准教授 (90378670)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Daiji 京都大学, 医学研究科, 研究員 (70456870)
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| Project Period (FY) |
2010 – 2012
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| Keywords | mDia / 難治性肺疾患 / 炎症 / 線維化 |
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| Research Abstract |
This study aims to analyze the roles of mDia known as Rho effectors in refractory pulmonary diseases and to elucidate their pathogenesis and develop novel therapies. In an acute asthma model, mice deficient in mDia1 showed less numbers of total cells and eosinophils and lower concentrations of Th2 cytokines in bronchoalveolar lavage fluid than wild-type mice. Airway hyperresponsiveness in asthmatic mice deficient in mDia1 was also reduced as compared to asthmatic wild-type mice. Thus, mDia1 contributes to allergic airway inflammation and can be a therapeutic target.
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[Journal Article] Measurement of dyspnea in patients with obstructive sleep apnea2013
Author(s)
Aihara K, Oga T, Yoshimura C, Hitomi T, Chihara Y, Harada Y, Murase K, Toyama Y, Tanizawa K, Handa T, Tsuboi T, Mishima M, Chin K
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Journal Title
Sleep Breath
Volume: 17(2)
Pages: 753-761
DOI
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