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2012 Fiscal Year Final Research Report

INVOLVMENT OF TH17 CELLS IN TUMOR ANGIOGENESIS INDUCED BY INTERACION BETWEEN NON-SMALL CELL LUNG CANCER CELLS AND INTERSTITIAL STROMAL CELLS

Research Project

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Project/Area Number 22590869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionJosai University

Principal Investigator

NUMASAKI Muneo  城西大学, 薬学部, 教授 (50344677)

Co-Investigator(Kenkyū-buntansha) HAGIWARA Kouiti   (00240705)
Co-Investigator(Renkei-kenkyūsha) TAGAWA Masatoshi   (20171572)
Project Period (FY) 2010 – 2012
Keywordsサイトカイン / 肺癌 / Th17 細胞 / 血管新生 / 血管新生因子
Research Abstract

Th17 cells were isolated and culture supernatants were collected. Culture supernatants of Th17 cells were found to have the activity to induce neovascular formation, and this activity was inhibited, in part, by an anti-IL-17 antibody.

  • Research Products

    (17 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells2012

    • Author(s)
      Fujie H、 Niu K、 Ohba M、Tomioka Y、Kitazawa H、Nagashima K、Ohrui T 、 Numasaki M
    • Journal Title

      Inflammation

      Volume: 35 Pages: 1119-1131

    • DOI

      DOI:10.1007/s10753-011-9419-0

    • Peer Reviewed
  • [Journal Article] Adenoviruses-mediated transduction of human oesophageal carcinoma cells with the interferon- genes produced anti-tumour effects2011

    • Author(s)
      Li Q、 Kawamura K、 Okamoto S、 Fujie H、Numasaki M、Namba M、Nagata M、Shimada H、 Kobayashi H、 Tagawa M
    • Journal Title

      Brit. J. Cancer

      Volume: 105 Pages: 1302-1132

    • DOI

      DOI:10.1038/bjc.2011.379

    • Peer Reviewed
  • [Journal Article] Antitumor activity of type III interferon alone or in combination with type I interferon against human non-small cell lung cancer2011

    • Author(s)
      Fujie H、 Tanaka T、Tagawa M、 Kaijun N、 Watanabe M、 Suzuki T、 Nakayama K、 Numasaki M
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 1977-1990

    • DOI

      DOI:10.1111/j.1349-7006.2011.02079.x

    • Peer Reviewed
  • [Journal Article] Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotic2011

    • Author(s)
      Fujie H、Villena J、 Tohno M、 Morie K、 Shimazu T、Aso H、 Suda Y、 Shimosato T、 Iwabuchi N、Xiao JZ、 Yaeshima T、 Iwatsuki K、 Saito T、 Numasaki M、 Kitazawa H
    • Journal Title

      FEMS Immunol. Med. Microbiol

      Volume: 63 Pages: 129-139

    • DOI

      DOI:10.1111/j.1574-695X.2011.00837.x

    • Peer Reviewed
  • [Journal Article] Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 42011

    • Author(s)
      Ueda W、 Tohno M、 Shimazu T、 Fujie H、Aso H、 Kawai Y、 Numasaki M、 Saito T、Kitazawa H
    • Journal Title

      Vet. Immunol. Immunopathol

      Volume: 143 Pages: 148-154

    • DOI

      DOI:10.1016/j.vetimm.2011.05.026

    • Peer Reviewed
  • [Journal Article] Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents2010

    • Author(s)
      Li Q、 Kawamura K、 Ma G、 Iwata F、 Numasaki M、 Suzuki N、 Shimada H、Tagawa M
    • Journal Title

      Eur. J. Cancer

      Volume: 46 Pages: 180-190

    • DOI

      DOI:10.1016/j.ejca.2009.10.002

    • Peer Reviewed
  • [Presentation] Toll-like receptor-2 activating bifidobacteria strains regulate inflammatory responces in porcine intestinal epithelial cells2011

    • Author(s)
      Fujie H、Villena J、Tohno M、Morie K、Shimazu T、Aso H、Suda Y、Shimosato T、Iwabuchi N、Xiao JZ、Yaeshima T、Iwatsuki K、Numasaki M、Kawai Y、Saito T、Kitazawa H
    • Organizer
      4th FEMS Congress of European Microbiologists
    • Place of Presentation
      スイス
    • Year and Date
      20110600
  • [Presentation] Th17 サイトカインと肺癌、シンポジウム 炎症と肺癌-発症、進展における共通のメカニズムを探る-2011

    • Author(s)
      沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20110400
  • [Presentation] IL-17 cytokine family IL-17A、IL-17A/F 及び IL-17F による気道上皮細胞のケモカイン産生の制御2011

    • Author(s)
      野口 愛、 沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20110400
  • [Presentation] IL-17 は、血管内皮細胞上のフラクタルカインが誘導するNK cell の活性化により腫瘍の肺転移を抑制する2011

    • Author(s)
      成井ももこ、沼崎宗夫
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      20110400
  • [Presentation] IL-17 は血管内皮細胞のフラクタルカインの発現を増強することにより腫瘍の肺転移を抑制する2010

    • Author(s)
      藤江瞳、 田川雅敏、 沼崎宗夫
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100900
  • [Presentation] インターフェロンラムダ発現型アデノウイルスによる食道がんに対する抗腫瘍効果2010

    • Author(s)
      田川雅敏、川村希代子、岡本慎也、楊珊、深町利彦、小林弘、藤江瞳、沼崎宗夫、島田英昭
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      20100900
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda produced anti-tumor effects to human esophageal carcinoma in vivo2010

    • Author(s)
      Msatoshi Tagawa 、 Quanhai Li 、 Kiyoko Kawamura 、 Shinya Okamoto 、 Shan Yang 、Hiroshi Kobayashi 、Muneo Numasaki 、Yuji Tada、 Kenzo Hiroshima、 and Hideaki Shimada
    • Organizer
      ASGCT 2010 Clinical Trials Training Course and 13th Annual Meeting
    • Place of Presentation
      アメリカ
    • Year and Date
      20100500
  • [Presentation] Adenoviruses-mediated expression and cell-mediated delivery of interferon-lambda achieve anti-tumor effects in vivo2010

    • Author(s)
      Msatoshi Tagawa 、 Quanhai Li 、 Kiyoko Kawamura、 Shinya Okamoto、 Shan Yang、 Hitomi Fujie 、Muneo Numasaki 、Hideaki Shimada 、and Hiroshi Kobayashi
    • Organizer
      第16回日本遺伝子治療学会
    • Place of Presentation
      栃木
    • Year and Date
      20100400
  • [Presentation] The additive cytostatic effect of Type I and Type IIIIFNs against human NSCLC2010

    • Author(s)
      Hitomi Fujie 、 Muneo Numasaki 、 and Hidenori Takahash
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      20100400
  • [Book] Type III Interferons IL-28 and IL-29: Novel Interferon Family Members with Therapeutic Potential in Cancer Therapy. In Advancements in Tumor Immunotherapy and Cancer Vaccines2011

    • Author(s)
      Fujie H 、Numasaki M
    • Total Pages
      175-196
    • Publisher
      In Advancements in Tumor Immunotherapy and Cancer Vaccines
  • [Remarks]

    • URL

      http://www.josai.ac.jp/~facpharm/pharma4/yk/department_of_nutritional_physiology.html

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Published: 2014-08-29   Modified: 2014-12-02  

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