2012 Fiscal Year Final Research Report
Roles of small G protein Rap1 in acute respiratory failure and its therapeutic implication
| Project/Area Number |
22590872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 急性呼吸不全 / 低分子G蛋白 / 接着分子 / シグナル伝達 |
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| Research Abstract |
We evaluated the role of Rap1, which regulates the expression of CD11b and CD44, in the pathogenesis of acute respiratory failure. Inflammatory stimulus upregulated the gene expression of Rap1 in cultured endothelial and epithelial cells. In addition, upr
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