Protection by hydrogen therapy against oxidative stress induced various lung diseases.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: TERASAKI Yasuhiro 日本医科大学, 医学部, 准教授 (50332870)
• Co-Investigator(Kenkyū-buntansha): OHSAWA Ikuro 日本医科大学, 老人病研究所, 教授 (30343586) ; FUKUDA Yuh 日本医科大学, 大学院・医学研究科, 教授 (60097037) ; TERASAKI Mika 日本医科大学, 医学部, 助教 (50372785)
• Project Period (FY): 2010 – 2012
• Keywords: 酸化ストレス / 水素還元力 / 呼吸器疾患

Research Abstract

Various lung injuries such as irradiation or anticancer drug induced injuries are reportedly initiated and sustained by oxidative stress (reactive oxygen species:ROS), especially hydroxyl radicals (-OH), which are the primary cause of the damage. As yet,no ideal ROS scavenge therapy has been established. Because H2 was recently reported as an efficient antioxidant that diffuses rapidly across cell membranes, selectively reduces -OH, and suppresses oxidative stress-induced injury with no known toxicity, we studied the possibility that H2 could protect against irradiation or anticancer drug induced lung damage. We show here that H2 scavenged -OH and protected against apoptotic damage related to oxidative stress induced by irradiation and anticancer drug in lung epithelial cells and in lungs of mice. H2 treatment will thus be valuable for protection against oxidative stress induced various lung diseases.

Research Products

• [Journal Article] 神経系における水素分子の抗酸化,抗炎症作用:研究の現状 (2012)
  • Author(s): 大澤郁朗
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 1320-1321
• [Journal Article] 水素分子の生理作用と水素水による疾患防御 (2012)
  • Author(s): 大澤郁朗
  • Journal Title: 日本老年医学会雑誌 Volume: 35 Pages: 680-688
  • Peer Reviewed
• [Journal Article] Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress (2011)
  • Author(s): Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, Fukuda Y
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 301(4) Pages: L415-26
  • Peer Reviewed
• [Journal Article] Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice (2011)
  • Author(s): Kamimura, N., Nishimaki, K., Ohsawa, I., Ohta, S
  • Journal Title: Obesity Volume: 19 Pages: 1396-1403
  • Peer Reviewed
• [Journal Article] 水素分子医学の現状と展望 (2011)
  • Author(s): 大澤郁朗
  • Journal Title: 基礎老化研究 Volume: 35 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Rapid Diffusion of Hydrogen Protects the Retina: Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury (2010)
  • Author(s): Oharazawa, H., Igarashi, T., Yokota, T., Fujii, H., Suzuki, H., Machide, M., Takahashi, H., Ohta, S., and Ohsawa, I
  • Journal Title: Invest.Ophthalmol. Vis. Sci Volume: 51 Pages: 487-492
  • Peer Reviewed
• [Presentation] Molecular hydrogen as a radioprotector: Possible mechanisms of hydrogen antioxidant activity (2013)
  • Author(s): 大澤郁朗
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 20130327-29
• [Presentation] Control by the hydrogen water of pulmonary damage by antineoplastic drug gefitinib (2013)
  • Author(s): Suzuki T, Hideo Kawaguchi H, Ohsawa I
  • Organizer: 国際シンポジウム「水・海洋・地球環境-俯 瞰的に考えるための知的体験」
  • Place of Presentation: 群馬県板倉& 東京
  • Year and Date: 20130316-19
• [Presentation] 水素水による抗がん剤ゲフィチニブの副作用抑制 (2013)
  • Author(s): 鈴木徹也、寺崎泰弘、川口英夫、大澤郁朗
  • Organizer: 第3回分子状水素医学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20130209-10
• [Presentation] 分子状水素によるNrf2を介した酸化ストレス抑制機構 (2013)
  • Author(s): 村上弥生、大澤郁朗
  • Organizer: 第3回分子状水素医学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20130209-10
• [Presentation] ガスメディエーターである水素分子の最新科学 (2013)
  • Author(s): 大澤郁朗
  • Organizer: 第6回電解水透析研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-02-02
• [Presentation] 水素分子による酸化ストレス防御の分子機構 (2012)
  • Author(s): 大澤郁朗、村上弥生
  • Organizer: 第12回日本ミトコンドリア学会年会
  • Place of Presentation: 筑波
  • Year and Date: 20121219-21
• [Presentation] 分子状水素による酸化ストレス抑制の分子機構 (2012)
  • Author(s): 大澤郁朗、村上弥生
  • Organizer: 日本基礎老化学会第35回大会
  • Place of Presentation: 船橋
  • Year and Date: 20120726-27
• [Presentation] Molecular Hydrogen Medicine: Possible Mechanisms of Hydrogen Antioxidant Activity (2012)
  • Author(s): Ohsawa I, Murakami Y, Aoki S, Tanaka M
  • Organizer: Annual Conference of the Korean Society for Gerontology, the 12th Korea-Japan Joint symposia
  • Place of Presentation: Osong, Republic of Korea
  • Year and Date: 20120614-15
• [Presentation] 分子状水素による放射線障害抑制とその分子機構 (2012)
  • Author(s): 大沢郁郎、寺崎泰弘、村上弥生
  • Organizer: 第2回分子状水素医学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20120200
• [Presentation] 眼科領域における水素水の可能性 (2012)
  • Author(s): 大澤郁朗
  • Organizer: 第6回眼抗加齢医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-16
• [Presentation] 抗酸化力を利用した水素分子治療による放射線肺障害の抑制 (2011)
  • Author(s): 寺崎泰弘、寺崎美佳、漆山博和、雨森俊介、福田悠
  • Organizer: 日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110400
• [Presentation] Hydrogen therapy attenuates radiation-induced pulmonary injury in C57/Bl6 mice through reducing oxidative stress (2010)
  • Author(s): Terasaki Y, Ohsawa I, Terasaki M, Kang D, Kuwahara N, Ishikawa, A, Takahashi M, Kunugi S, , Fukuda Y
  • Organizer: ATS International Conference
  • Place of Presentation: New Orleans, USA
  • Year and Date: 20100500
• [Book] 抗酸化力を利用した水素分子治療による肺障害の抑制と応用びまん性肺疾患に関する調査研究平成24年度研究報告書 (2013)
  • Author(s): 寺崎泰弘、鈴木徹也、大澤郁朗、漆山博和、寺崎美佳、高橋美紀子、功刀しのぶ、石川吾利美、桑原尚美、福田悠
  • Total Pages: 335-344