2012 Fiscal Year Final Research Report
Molecular Characteristics and Regulations Associated with Lung Carcinogenesis in Never-Smoker
| Project/Area Number |
22590874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Saitama Medical University |
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Principal Investigator |
OKANO Tetsuya 埼玉医科大学, 医学部, 講師 (00339376)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロ RNA / 非喫煙者肺がん / プロテオーム |
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| Research Abstract |
Lung cancers in never-smokers have unique miRNA expression profiles as a novel molecular characteristic. MiR-21 is a downstreameffector of the activated EGFR signaling pathway and can be a therapeutic target in lung cancers with and without EGFR mutations. MiR-138 on 3p21.33, a chromosomal region carrying a long-sought lung cancer suppressor gene, is downregulated in never-smoker cases. There is an inverse correlation between miR-138 and hTERTin never-smoker lung cancers. These miRNAs may play an oncogenic role in lung carcinogenesis and miR-21 is novel molecular targets in treatment of lung cancers in never-smokers.
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[Journal Article] GemmaA Alternating chemotherapy with amrubicin plus cisplatin and weekly administration of irinotecan plus cisplatin for extensive-stage small cell lung cancer.2013
Author(s)
Noro R, Yoshimura A, Yamamoto K, Miyanaga A, Mizutani H, Minegishi Y, Seike M, Kubota K, Kosaihira S, Hino M, Ando M, Nomura K, Okano T, Kobayashi K, Uematsu K
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Journal Title
Anticancer Res.
Volume: 33(3)巻
Pages: 1117-23
Peer Reviewed
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[Journal Article] Gemma A Combination chemotherapy of alternating etoposide and carboplatin with weekly administration of irinotecan and cisplatin in extensive-stage small-cell lung cancer.2012
Author(s)
Yoshimura A, Noro R, Miyanaga A, Mizutani H, Kosaihira S, Minegishi Y, Seike M, Hino M, Ando M, Nomura K, Okano T, Kobayashi K
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Journal Title
Anticancer Res
Volume: 32(10)巻
Pages: 4473-8
Peer Reviewed
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[Journal Article] Gemma A.Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules.2012
Author(s)
Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A
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Journal Title
Br J Cancer.
Volume: 106巻
Pages: 867-75
Peer Reviewed
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[Journal Article] Successful treatment of carcinomatous meningitis with erlotinib and whole brain radiotherapy.2012
Author(s)
Rinako Ishikawa, Tetsuya Okano, Nobuyuki Koyama, Erika Saito, Akiko Kaga , Harue Utsugi, Tomohiko Mio, Hisayoshi Daito, Yuri Maeno, Yuka Uchida, Yoshiaki Nagai, Yoshitake Murayama, Kunihiko Kobayashi
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Journal Title
Ann. Cancer Res. Ther.
Volume: 20(2)巻
Pages: 58-62
Peer Reviewed
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[Journal Article] The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias.2011
Author(s)
Minegishi Y, Kuribayashi H, Kitamura K, Mizutani H, Kosaihira S, Okano T, Seike M, Azuma A, Yoshimura A, Kudoh S, Gemma A.
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Journal Title
J Thorac Oncol.
Volume: 6(4)巻
Pages: 801-7
Peer Reviewed
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