2012 Fiscal Year Final Research Report
Analysis of T helper (Th) cell responses in immune complex nephritis with Th1/Th2/Th17 dominant mice
| Project/Area Number |
22590876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YOH Keigyou 筑波大学, 医学医療系, 准教授 (90323302)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腎臓学 / Th17細胞 |
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| Research Abstract |
To clarify the roles of helper T cell in immune complex glomerulonephritis, we induced experimental immune complex glomerulonephritis in Th1/2/17 dominant transgenic mice. Th17 dominant transgenic mice showed higher volume of proteinuria than other mice, and developed crescentic glomerulonephritis. These results suggested that Th17 might play an important role in the development of immune complex glomerulonephritis.
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[Journal Article] Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice2012
Author(s)
K. Yoh, N. Morito, M. Ojima, K. Shibuya, Y. Yamashita, Y. Morishima, Y. Ishii, M. Kusakabe, H. Nishikii, A. Fujita, E. Matsunaga, M. Okamura, M. Hamada, A. Suto, H. Nakajima, A. Shibuya, K. Yamagata, S. Takahashi
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Journal Title
European Journal of Immunology
Volume: 42(8)
Pages: 1999-2009
DOI
Peer Reviewed
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