2012 Fiscal Year Final Research Report
Therapeutic approaches of AKI by adipose-derived mesenchymal cells, and urinary biomarker search in AKI
| Project/Area Number |
22590883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WADA Takashi 金沢大学, 医学系, 教授 (40334784)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / 虚血腎障害 / 脂肪由来間葉系細胞 / 質量分析計 / IP-10 / 再生 |
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| Research Abstract |
everal urinary biomarker candidates of acute kidney injury were detected by mass spectrometry. We also detected several urinary biomarker candidates of acute kidney injury by multiple cytokine/chemokine detection methods. In this study, we explored the effects of adipose-derived mesenchymal cells on a mouse model of AKI. The effects of adipose-derived mesenchymal cells were evaluated in AKI mouse model. A lthough, administered adipose-derived mesenchymal cells were tend to home into lung, repeated administration of adipose-derived mesenchymal cells reduced acute tubular necrosis and interstitial macrophage infiltration.
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[Journal Article] Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury2012
Author(s)
Furuichi K, Kokubo S, Hara A, Imamura R, Wang Q, Kitajima S, Toyama T, Okumura T, Matsushima K, Suda T, Mukaida N, Kaneko S, Wada T
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Journal Title
Nephron Extra
Volume: 2
Pages: 27-38
DOI
Peer Reviewed
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