2012 Fiscal Year Final Research Report
Mode of existence and cell division and multi-drug resistance of progenitor-like cells in distal area of S3 segment of proximal tubules
| Project/Area Number |
22590884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Hideo 浜松医科大学, 医学部, 助教 (60432209)
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| Research Collaborator |
FUJIKURA Yomoyuki 浜松医科大学, 医学部, RA (00444349)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 急性腎障害 / 近位尿細管細胞 / 再生 / 前駆様細胞 |
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| Research Abstract |
We investigated the possibility that the initially proliferating cells （target cells） which are responsible for recovering the damaged proximal tubules are progenitor-like cells in tubules in acute kidney injury model of rat. The target cells showed unequal cell division which is characterized in stem cells and more than one such a cell located in the same nephron. ABC transporter as multiple drug resistant phenotype in the isolated target cells were not different from those in other proximal tubular cells, but the target cells were resistant to urnaly acetate and 5-fluorouracil. The data support the possibility that the target cells are tubular epithelial progenitor-like cells.
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