The role of autophagy in renal ischemia-reperfusion injury

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: KITAMURA Harumi 大阪大学, 大学院・医学系研究科, 特任助教 (60570356)
• Co-Investigator(Kenkyū-buntansha): ISAKA Yoshitaka 大阪大学, 大学院・医学系研究科, 准教授 (00379166) ; TAKABATAKE Yoshitsugu 大阪大学, 大学院・医学系研究科, 助教 (30403075)
• Project Period (FY): 2010 – 2012
• Keywords: オートファジー / シスプラチン / タンパク凝集体 / 虚血再還流 / 近位尿細管 / ミトコンドリア

Research Abstract

In kidney, proximal tubules consume a large amount of energy in the process of electrolyte reabsorption. These tubules contain large quantities of mitochondria which provide the energy for this reabsorption. Proximal tubules are susceptible to many kinds of insults such as ischemia-reperfusion injury and nephrotoxic substrates, but little is known of the factors that counteract cellular stress signaling pathways. Autophagy mediates bulk degradation and recycling of cytoplasmic constituents to maintain cellular homeostasis. We demonstrated the critical role of autophagy in normal proximal tubule function and protection against acute tubular injury including ischemia-reperfusion injury and cisplatin nephrotoxicity.

Research Products

• [Journal Article] Chloroquine in cancer therapy: a double-edged sword of autophagy. (2013)
  • Author(s): Kimura T, Takabatake Y, Takahashi A, Isaka Y
  • Journal Title: Cancer Res. Volume: 73 Pages: 3-7
• [Journal Article] Autophagy guards against cisplatin-induced acute kidney injury (2012)
  • Author(s): Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H.
  • Journal Title: Am J Pathol Volume: 180 Pages: 517-25
• [Journal Article] The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells (2011)
  • Author(s): Isaka Y, Kimura T, Takabatake Y
  • Journal Title: Autophagy. Volume: 7 Pages: 1085-7
• [Journal Article] Autophagy protects the proximal tubule from degeneration and acute ischemic injury (2011)
  • Author(s): Kimura T, Takabatake Y, Takahashi A, Kaimori JY, Matsui I, Namba T, Kitamura H, Niimura F, Matsusaka T, Soga T, Rakugi H, Isaka Y
  • Journal Title: J Am Soc Nephrol Volume: 22 Pages: 902-13
• [Presentation] オートファジーはシスプラチンによる急性腎障害の進行を防御する (2012)
  • Author(s): 高橋 篤史
  • Organizer: 55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-12
• [Presentation] オートファジーは近位尿細管細胞のホメオスタシスを維持する (2011)
  • Author(s): 高畠 義嗣
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 急性腎障害に対抗するオートファジー (2011)
  • Author(s): 木村友則
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17
• [Presentation] 腎尿細管でのオートファジー (2011)
  • Author(s): 木村友則
  • Organizer: 第1回オートファジー研究会
  • Place of Presentation: 静岡県掛川市
  • Year and Date: 2011-01-13
• [Book] オートファジー不全による尿細管障害 (2013)
  • Author(s): 猪阪善隆、木村友則、高畠義嗣
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/index.html