2012 Fiscal Year Final Research Report
Association of serum cystatin C with the risk of the development of cardiovascular disease in a general Japanese population: the Hisayama Study
| Project/Area Number |
22590892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Yutaka 九州大学, 医学研究院, 教授 (80161602)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腎臓学 / 心臓病 / 認知症 |
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| Research Abstract |
The aims of this project were to investigate the association of sCysC on the risk of atherosclerotic disease among 3,328 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between sCysC and prevalence of peripheral arterial disease (PAD) defined as ankle-brachial index <0.9. As a result, the unadjusted prevalence of PAD increased linearly with elevating sCysC levels. However, there was no evidence of the significant relationship in the multivariate-adjusted analysis. Next, we estimated the association of sCysC and the cardiovascular risk in an average 7.1-year follow-up study conducted in the above population. Higher sCysC levels were associated significantly with the unadjusted incidence of cardiovascular disease, but this significant association disappeared after adjusting confounding factors.Finally, we assessed the relationship between estimated glomerular filtration rate with sCysC (eGFR-CysC) and the risk of incident cardiovascular disease and all-cause mortalityin the above follow-up data. Lower eGFR-CysC was a risk factor for the incident cardiovascular disease and all-cause mortality.
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Research Products
(4 results)
