2012 Fiscal Year Final Research Report
Role of Rh/Rho-kinase pathway in the pathogenesis of diabetic nephropathy
| Project/Area Number |
22590900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖尿病 / 糖尿病腎症 / Rho / Rhoキナーゼ |
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| Research Abstract |
Rho/ROCK pathway regulates various cellular functions. In this study, we found that Rho/ROCK pathway is activated in renal cortex of db/db mouse and involved in upregulation of pro-inflammatory cytokines in cultured mesangial cells, suggesting critical role of Rho/ROCK pathway played inthe pathogenesis of diabetic nephropathy.
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Research Products
(27 results)
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[Journal Article] Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1a2013
Author(s)
Matoba K, Kawanami D, Okada R, Tsukamoto M, Kinoshita J, Ito T,Ishizawa S, Kanazawa Y, Yokota Y, Murai N, Matsufuji S, Utsunomiya K.
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Journal Title
Kideny Int
Volume: (in press)
DOI
Peer Reviewed
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