2012 Fiscal Year Final Research Report

Functional Analysis of fatty acid binding protein in hypertensive renal injury

Research Project

Project/Area Number	22590901
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Kidney internal medicine
Research Institution	St. Marianna University School of Medicine
Principal Investigator	IKEMORI Atsuko 聖マリアンナ医科大学, 医学部, 准教授 (80350635)
Co-Investigator(Kenkyū-buntansha)	SUGAYA Takeshi 聖マリアンナ医科大学, 医学部, 客員教授 (40381561) KIMURA Kenjiro 聖マリアンナ医科大学, 医学部, 教授 (00161555)
Project Period (FY)	2010 – 2012
Keywords	L-FABP / 腎疾患 / 高血圧 / 治療 / 高血圧性腎障害 / アンジオテンシン II / 尿細管間質障害
Research Abstract	Angiotensin II was infused systemically into human liver type fatty acid binding protein(L-FABP) chromosomal transgenic (Tg) and wild type (WT) mice for 4 weeks. Although blood pressure levels in both groups increased to a similar extent, expressions of inflammatory cytokines and collagen type I or III were significantly attenuated in the Tg mice compared to the WT mice. The expression of L-FABP increased in the Tg mice by Ang II infusion and the accumulation of peroxidative products was significantly inhibited in the Tg mice than in the WT mice. From these results, renal L-FABP attenuated the hypertensive renal injury independent on blood pressure.

(5 results)