2012 Fiscal Year Final Research Report
Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-
| Project/Area Number |
22590903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
OKUDA Seiya 久留米大学, 医学部, 教授 (80158823)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Seiji 久留米大学, 医学部, 准教授 (80322593)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メタボリック症候群 / インスリン抵抗性 / 慢性腎臓病 / ADMA |
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| Research Abstract |
Metabolic syndrome (MetS) is a strong risk factor for the initiation and development of chronic kidney disease (CKD). One possible factor that could explain this link seems to be endothelial dysfunction (ED). In CKD patients, ADMA levels were associated with metabolic factors and eGFR. Further, increased ADMA levels were associated with surrogate markers for cardiovascular disease as well as annual reduction rates of GFR. Animal models of MetS revealed that dysregulation of DDAH, an enzyme for ADMA could account for ADMA elevation, and therefore could contributed to the development and progression of cardiovascular disease as well as renal injury in Mets.
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[Journal Article]2009
Author(s)
Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S.
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Journal Title
Nephrol Dial Transplant.
Volume: 24(4)
Pages: 1162-9
Peer Reviewed
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[Journal Article] Involvement of advanced glycation end product?induced asymmetric dimethylarginine generation in endothelial dysfunction.
Author(s)
Ando R, Ueda S, Yamagishi S, Miyazaki H, Kaida Y, Kaifu K, Yokoro M, Nakayama Y, Obara N, Fukami K, Takeuchi M, Okuda S.
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Journal Title
Diabetes & Vascular Disease Research.
Peer Reviewed
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