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2012 Fiscal Year Final Research Report

Novel therapeutic approach against receptor for advanced glycation end products in patients with diabetic nephropathy or RPGN.

Research Project

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Project/Area Number 22590904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionKurume University

Principal Investigator

FUKAMI Kei  久留米大学, 医学部, 准教授 (80309781)

Project Period (FY) 2010 – 2012
Keywordsdiabetic nephropathy / RPGN / glycation / RAGE
Research Abstract

Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We examined effects of AGE- and RAGE-aptamer on renal injury in KKAy/Ta mice. Glomerular AGEs levels were significantly increased in KKAy/Ta mice, which were blocked by AGEs-aptamer. Urinary albumin and 8-hydroxy-2’-deoxy-guanosine levels were increased, and glomerular hypertrophy and extracellular matrix accumulation were prevented by AGEs-aptamer. Our present data suggest that continuous administration of AGEs-aptamer may be a feasible and promising therapeutic strategy for the treatment of diabeticnephropathy.

  • Research Products

    (31 results)

All 2013 2012 2011

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (5 results) Book (8 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Telmisartan inhibits AGE-induced podocyte damage and detachment.2013

    • Author(s)
      Fukami K,Yamagishi S, Kaifu K, Matsui T, Kaida Y, Ueda S, Takeuchi M, Asanuma K, Okuda S.
    • Journal Title

      Microvasc Res.

    • Peer Reviewed
  • [Journal Article] DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.2013

    • Author(s)
      Kaida Y, Fukami K, Matsui T, Higashimoto Y, Nishino Y, Obara N, Nakayama Y, Ando R, Toyonaga M, Ueda S, Takeuchi M, Inoue, H, Okuda S, Yamagishi
    • Journal Title

      Diabetes(S. Kaida Y and Fukami K contributed equally to this study)

    • Peer Reviewed
  • [Journal Article] Evidence for a positive association between serum carnitine and free testosterone levels in uremic men with hemodialysis.2013

    • Author(s)
      Sakai K, Fukami K, Yamagishi S, Kaida Y, Adachi T, Ando R, Manabe R, Otsuka A, Sugi K, Ueda S and Okuda S.
    • Journal Title

      Rejevenation Res.

    • Peer Reviewed
  • [Journal Article] AGEs-RAGE system in cardiovasculardisease.2013

    • Author(s)
      Fukami K, Yamagishi S, Okuda S.
    • Journal Title

      Cur Pharm Des

    • Peer Reviewed
  • [Journal Article] Effects of Switching from Calcium Carbonate to Lanthanum Carbonate on Bone Mineral Metabolism in Hemodialysis Patients.2013

    • Author(s)
      Manabe R, Fukami K, Ando R, Sakai K, Kusumoto T, Hazama H, Adachi T, Kaida K, Nakayama N, Ueda S, Kohno K, Wada Y, Yamagishi S, Okuda S.
    • Journal Title

      Ther Apher Dial. 17Suppl

      Volume: 1 Pages: 35-40

    • Peer Reviewed
  • [Journal Article] First reported case of collagenofibrotic glomerulopathy with a full-house pattern of immune deposits.2013

    • Author(s)
      Fukami K, Yamagishi S, Minezaki TNishi S, Hisano S, Okuda S.
    • Journal Title

      Clin Nephrol.

    • Peer Reviewed
  • [Journal Article] Glucagon-like Peptide-1 Receptor Agonist Inhibits Asymmetric Dimethylarginine Generation in the Kidney of Streptozotocin-Induced Diabetic Rats by Blocking Advanced Glycation End Product-Induced Protein Arginine Methyltranferase-1 Expression.2013

    • Author(s)
      Ojima A, Ishibashi Y, Matsui T, Maeda S, Nishino Y, Takeuchi M, Fukami K, Yamagishi SI. Am J Pathol.
    • Journal Title

      Am J Pathol.

      Volume: 182(1) Pages: 132-41

    • Peer Reviewed
  • [Journal Article] Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in non-alcoholic fatty liver disease patients.2013

    • Author(s)
      Hyogo H, Yamagishi S, Maeda S, Fukami K, Ueda S, Okuda S, Nakahara T, Kimura Y, Ishitobi T, Kazuki C.
    • Journal Title

      Clin Exp Med.

    • Peer Reviewed
  • [Journal Article] PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation.2013

    • Author(s)
      Ishibashi Y, Matsui T, Ohta K, Tanoue R, Takeuchi M, Asanuma K, Fukami K, Okuda S, Nakamura K, Yamagishi S.
    • Journal Title

      Microvasc Res

      Volume: (85) Pages: 54-8

    • Peer Reviewed
  • [Journal Article] Experimentaldiabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice.2013

    • Author(s)
      Takamiya Y, Fukami K, Yamagishi S, Kaida Y, Nakayama Y, Obara N, Iwatani R, Ando R, Koike K, Matsui M, Nishino Y, Ueda S, Cooper ME, and Okuda S.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 28(1) Pages: 55-62

    • Peer Reviewed
  • [Journal Article] Decreased serum carnitine is independently correlated with increased tissue accumulation levels of advanced glycation end products in hemodialysis patients.2012

    • Author(s)
      Adachi T, Fukami K, Yamagishi S, Kaida Y, Ando R, Sakai K, Adachi H
    • Journal Title

      Otsuka A, Ueda S, Sugi Kand Okuda S. Nephrology

      Volume: 17(8) Pages: 689-94

    • Peer Reviewed
  • [Journal Article] Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.2012

    • Author(s)
      Kaida Y, Ueda S, Yamagishi S, Nakayama Y, Ando R, Iwatani R, Fukami K, Okuda S.
    • Journal Title

      Life sciences

      Volume: 24(91) Pages: 301-305

    • Peer Reviewed
  • [Journal Article] Role of advanced glycation end products (AGEs) oxidative stress in vascular complications in diabetes.2012

    • Author(s)
      Yamagishi SI, Maeda S, Matsui T, Ueda S, Fukami K, Okuda S.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1820(5) Pages: 663-671

    • Peer Reviewed
  • [Journal Article] A new vasculitis activity score for predicting deathin myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis patients.2011

    • Author(s)
      Koike K, Fukami K, Yonemoto K, Iwatani R, Obara N, Ueda K,Toyonaga M, Ueda S, Ohara A, Takeda K, Yamagishi S, Okuda S.
    • Journal Title

      Am J Nephrol.

      Volume: 35(1) Pages: 1-6

    • Peer Reviewed
  • [Journal Article] Beneficial cardiometabolic actions of telmisartan plus amlodipine therapy in elderly patients with poorly controlled hypertension.2011

    • Author(s)
      Bekki H, Yamamoto K, Sone M, Homma T, Nakata M, Nohara M, Fukami K, Okuda S, Yamagishi S. C
    • Journal Title

      lin Cardiol.

      Volume: 34(4) Pages: 261-5

    • Peer Reviewed
  • [Journal Article] Tissue level of advanced glycation end products (AGEs) is an independent determinant of high sensitive C-reactive protein levels in hemodialysis patients.2011

    • Author(s)
      Makio Nagano, Kei Fukami, Sho-ichi Yamagishi, Kazuko Sakai, Yusuke Kaida, Takafumi Matsumoto, Takuma Hazama, Masahiro Tanaka,1 Seiji Ueda, and Seiya Okuda.
    • Journal Title

      Nephrology.

      Volume: 16(3) Pages: 299-303

    • Peer Reviewed
  • [Journal Article] Pigment epithelium-derived factor (PEDF) inhibits proximal tubular cell injury in early diabetic nephropathy by suppressing advanced glycation end products (AGEs)-receptor (RAGE) axis.2011

    • Author(s)
      Maeda S, Matsui T, Takeuchi M, Yoshida Y, Yamakawa R, Fukami K, Yamagishi SI.
    • Journal Title

      Pharmacol Res.

      Volume: 63(3) Pages: 241-8

    • Peer Reviewed
  • [Presentation] DNA aptamer raised against AGEs improves diabetic nephropathy in KK/Ay-Ta miceKei Fukami2013

    • Author(s)
      Sho-ichi Yamagishi, Yusuke Kaida, Yuichiro Higashimoto, Masayoshi Takeuchi, Hiroyoshi Inoue, Seiya Okuda.
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20130315-0317
  • [Presentation] DNA aptamer raised against AGEs improves diabetic nephropathy in KK/Ay-Ta miceNana Obara2012

    • Author(s)
      Kei Fukami, Sho-ichi Yamagishi, Yusuke Kaida, Yuichiro Higashimoto, Masayoshi Takeuchi, Seiji Ueda, Hiroyoshi Inoue, Seiya Okuda.
    • Organizer
      2012 International Symposium on the Maillard Reaction | IMARS.
    • Place of Presentation
      Nancy, France
    • Year and Date
      20120916-0920
  • [Presentation] DNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta mice.2011

    • Author(s)
      Yusuke Kaida , Kei Fukami, Sho-ichiYamagishi, Yuichiro Higashimoto, Nana Obara, Ryotaro Ando, Yosuke Nakayama, Masayoshi Takeuchi, Takanori Matsui, Seiji Ueda, Hiroyoshi Inoue, Seiya Okuda.
    • Organizer
      American Society of Nephrology.
    • Place of Presentation
      Philadelphia, Pennsylvania
    • Year and Date
      20111110-1112
  • [Presentation] AGEs-DNAアプタマーは糖尿病腎症の糸球体硬化を改善する2011

    • Author(s)
      甲斐田裕介、深水圭、上田誠二、山岸昌一、奥田誠也
    • Organizer
      日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20110615-0617
  • [Presentation] DNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta miceDNA aptamers raised against AGEs improve diabetic nephropathy in KK/Ay-Ta miceKei Fukami, Sho-ichi Yamagishi, Yuichiro Higashimoto2011

    • Author(s)
      Yusuke Kaida, Ryuji Iwatani, Ryotaro Ando, Yosuke Nakayama, Masayoshi Takeuchi, Takanori Matsui, Seiji Ueda, Hiroyoshi Inoue, Seiya Okuda.
    • Organizer
      International Society of Nephrology.
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      20110408-0412
  • [Book] Visual糖尿病臨床のすべて 糖尿病性腎症のすべて;腎症の治療・管理・対策とそのエビデンス深水2012

    • Author(s)
      圭、奥田誠也
    • Total Pages
      168-175
    • Publisher
      中山書店
  • [Book] AGEs と老化 Chapter 1 AGEs 化反応の基礎AGEs 受容体 深水 圭2012

    • Author(s)
      奥田誠也
    • Publisher
      メディカルレビュー社
  • [Book] 腎と透析 糖尿病性腎症への挑戦AGE の腎症進展における役割と治療法開発 への期待 深水 圭2012

    • Author(s)
      奥田誠也
    • Total Pages
      134-138
  • [Book] Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome Chapter 12 P An Overview of Diabetic NephropathyKei Fukami2012

    • Author(s)
      Sho-ichi Yamagishi
    • Total Pages
      145-153
  • [Book] 日本臨床腎臓症候群(下巻) 糖尿病にみられる急性腎不全2011

    • Author(s)
      奥田誠也
    • Total Pages
      137-140
    • Publisher
      深水圭
  • [Book] 糖尿病と酸化ストレス(メディカルレビュー)P 糖尿病患者の酸化ストレスマーカー・AGE/PEDF2011

    • Author(s)
      山岸昌一、奥田誠也
    • Total Pages
      149-153
    • Publisher
      深水圭
  • [Book] テルミサルタンのすぐれた降圧効果と高い忍容性2011

    • Author(s)
      山岸昌一、戸次久敏、山本喜一郎、曽根正好、中田真詩、野原正敏、深水圭、奥田誠也血圧第18巻、第7号
    • Total Pages
      54-58
  • [Book] 留米医学会雑誌 終末糖化産物からみた慢性腎臓病(CKD)の病態解明と治療戦略2011

    • Author(s)
      深水圭久
    • Total Pages
      95-100
  • [Patent(Industrial Property Rights)] AGE特異的アプタマーの腎疾患治療用途2011

    • Inventor(s)
      深水圭
    • Industrial Property Rights Holder
      深水圭、山岸昌一、井上浩義、奥田誠也
    • Industrial Property Number
      特許PCT/JP2011/077062
    • Filing Date
      2011-11-24
    • Overseas

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Published: 2014-08-29  

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