2012 Fiscal Year Final Research Report
Basic Research toward Discovery for New Renal Treatment using Bioactive Peptides
| Project/Area Number |
22590906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YOSHIHARA Fumiki 独立行政法人国立循環器病研究センター, 病院, 医長 (70393220)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUDOME Takeshi 独立行政法人国立循環器病研究センター, 研究所, 室長 (00443474)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生理活性ペプチド / 腎疾患 |
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| Research Abstract |
Chronic angiotensin II (Ang II) infusion promotes renal interstitial fibrosis. To evaluate the pathophysiological significance of the natriuretic peptide-GC-A system, we infused Ang II in GC-A-deficient mice (GC-A-KO) and wild mice. The natriuretic peptide-GC-A system may play an inhibitory role in Ang II-induced renal tubular atrophy, interstitial fibrosis, and phenotypic transformation in renal tubular cells and fibroblasts. Renal blood flow evaluated using microspheres was significantly lower in GC-A-KO mice than that in wild mice. The reduction of renal blood flow in GC-A-KO mice relative to that in wild mice may be one possibility for advanced renal tubular damage and interstitial fibrosis in Ang II-infused GC-A-KO.
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[Journal Article] Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population.2011
Author(s)
Kamide K, Kokubo Y, Yang J, Takiuchi S, Horio T, Matsumoto S, Banno M, Matayoshi T, Yasuda H, Miwa Y, Yoshihara F, Nakamura S, Nakahama H, Iwashima Y, Oguro R, Ohishi M, Rakugi H, Okamura T, Miyata T, Kawano Y.
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Journal Title
Hypertens Res.
Volume: 34(6)
Pages: 740-746
Peer Reviewed
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