Evaluation of the mechanisms to progress hypertension and kidney injury in high fat loading during young age

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: ANDO Katsuyuki 東京大学, 医学部附属病院, 特任准教授 (60184313)
• Project Period (FY): 2010 – 2012
• Keywords: 肥満 / 高血圧 / 腎障害

Research Abstract

To elucidate the relationship of obesity and high salt intake due to overeating during young age in the progress of hypertension, the effects of restriction of dietary amount, salt, and both were examined in in DahlS.Z-Leprfa rats, which show obesity, hypertension, and kidney injury during young age. As a result, these treatments ameliorate hypertension and the associated kidney injury. Thus, dietary factors during young age may play an important role of hypertension. In addition, the present data suggests contribution of aldosterone in development of hypertension at young age.

Research Products

• [Journal Article] B-type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction. (2013)
  • Author(s): Sadanaga T, Ando K, Hirota S, Mitamura H, Tsuchihashi T, Kohsaka S, Fukuda K, Ogawa S.
  • Journal Title: Intern Med J.
• [Journal Article] Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. (2012)
  • Author(s): Fujita M, Ando K, Kawarazaki H, Kawarasaki C, Muraoka K, Ohtsu H, Shimizu H, Fujita T
  • Journal Title: Hypertension Volume: 59 Pages: 105-112
• [Journal Article] Reactive oxygen species and the central nervous system in salt-sensitive hypertension: possible relationship to obesity-induced hypertension. (2012)
  • Author(s): Ando K, Fujita M.
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 39 Pages: 111-116
• [Journal Article] Pathophysiology of salt-sensitive hypertension. (2012)
  • Author(s): Ando K, Fujita T.
  • Journal Title: Ann Med Volume: 44 Pages: S119-S126
• [Journal Article] Kidney transplantation restored uncoupled bone turnover in end-stage renal disease. (2012)
  • Author(s): Kawarazaki H, Shibagaki Y, Kido R, Nakajima I, Fuchinoue S, Ando K, Fujita T, Fukagawa M, Teraoka S, Fukumoto S.
  • Journal Title: Clin Nephrol. Volume: 78 Pages: 10-16
• [Journal Article] Mineralocorticoid receptor-Rac1activation and oxidative stress play major roles in salt-induced hypertension and kidney injury in prepubertal rats. (2012)
  • Author(s): Kawarazaki H, Ando K, Shibata S, Muraoka K, Fujita M, Kawarazaki C, Fujita T.
  • Journal Title: J Hypertens. Volume: 30 Pages: 1977-85
• [Journal Article] Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. (2011)
  • Author(s): Ishikawa A, Kawarazaki H, Ando K,Fujita M, Fujita T, Homma Y.
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 30-33
• [Journal Article] Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats. (2011)
  • Author(s): Kawarazaki H, Ando K, Fujita M, Matsui H, Nagae A, Muraoka K, Kawarasaki C, Fujita T.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 300 Pages: F1402-F1409
• [Journal Article] Rac1 GTPase in rodent kidneys is essentialfor salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. (2011)
  • Author(s): Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T.
  • Journal Title: J Clin Invest. Volume: 121 Pages: 3233-3243
• [Journal Article] Design and rationale of Japanese Evaluation between Formula of Azelnidipine and Amlodipine Add on Olmesartan to Get Antialbuminuric Effect Study (J-FLAG): Evaluation of the antialbuminuric effects between calcium channel blocker with sympatholytic action in hypertensive patients with diabetes and albuminuria. (2011)
  • Author(s): Ando K, Haneda M, Ito S, Kashihara N, Node K, Nangaku M, Shimosawa T, Kishimoto J, Fujita T
  • Journal Title: Cardiovasc Drugs Ther Volume: 25 Pages: 341-7
• [Journal Article] Naturalhistory of mineral and bone disorders after living donorkidney transplantation; One-year prospective observational study. (2011)
  • Author(s): Kawarazaki H, Shibagaki Y, Fukumoto S, Kido R, Ando K, Nakajima I, Fuchinoue S,Fujita T, Fukagawa M, Teraoka S.
  • Journal Title: Ther Apher Dial. Volume: 15 Pages: 481-487
• [Journal Article] on behalf of the SAKURA Trial Investigators. Design and rationale of the Study of Assessment for Kidney function by Urinary microalbumin in RAndomized (SAKURA) trial: Comparison of the antialbuminuric effects between L-/N-type and L-type calcium channel blocker in hypertensive patients with diabetes and microalbuminuria. (2011)
  • Author(s): Matsuoka H, Ando K, Ueshima K, Babazono T, Kario K, Sato T, Nakao K, Fujita T
  • Journal Title: Clin Exp Hypertens. Volume: 33 Pages: 455-462
• [Journal Article] Protective effect of dietary potassium against cardiovascular damage in salt-sensitive hypertension: Possible role of its antioxidant action. (2010)
  • Author(s): Ando K, Matsui H, Fujita M, Fujita T:
  • Journal Title: Curr Vasc Pharmacol Volume: 8 Pages: 59-63
• [Journal Article] Rationale, design, and baseline data of the Japanese Primary Prevention Project (JPPP)A randomized open-label controlled trial of versus no aspirin in patients with multiple risk factors for vascular events. (2010)
  • Author(s): Teramoto T, Shimada K, Uchiyama S, Sugawara M, Goto Y, Yamada N, Oikawa S, Ando K, Ishizuka N, Yamazaki T, Yokoyama K, Murata M, Ikeda Y
  • Journal Title: Am Heart J Volume: 159 Pages: 361-369.e4.
• [Journal Article] Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Treatment Effect (EVALUATE) Trial: A double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria. (2010)
  • Author(s): Ando K, Ohtsu H, Arakawa Y, Kubota K, Yamaguchi T, Nagase M, Yamada A, Fujita T
  • Journal Title: Hyperterns Res Volume: 33 Pages: 616-621
• [Journal Article] Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. (2010)
  • Author(s): Kawarazaki H, Ando K, Nagae A, Fujita M, Matsui H, Fujita T.
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 2879-2889
• [Presentation] Brain Mineralocorticoid receptor activation mediates arterial pressure elevation brain oxidative stress-induced sympathoactivation in salt-sensitive and obesity-induced hypertension. (2012)
  • Author(s): Fujita M, Ando K, Kawarazaki C,Muraoka K, Fujita T.
  • Organizer: The 24th Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney
  • Year and Date: 20120930-1004
• [Presentation] Glomerular targeted molecular therapy using tyrosin hydroxylase siRNA ameliorates glomerular damage in DOCA-salt rats. (2012)
  • Author(s): Kawarazaki C, Fujita M, Shimizu H, Muraoka K, Hori Y, Kaname S, Nishiyama N, Kataoka K, Ando K, Fujita T.
  • Organizer: The 24th Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney
  • Year and Date: 20120930-1004
• [Presentation] The role of aldosterone in the development of murine lupus nephritis. (2012)
  • Author(s): Muraoka K, Ando K, Fujita M,Kawarazaki C, Shimizu H, Hirahashi J, Fujita T.
  • Organizer: The 24th Meeting of the International Society of Hypertension (
  • Place of Presentation: Sydney
  • Year and Date: 20120930-1004
• [Presentation] Comparison of the Antialbuminuric Effects between L-/N-Type and L-Type Calcium Channel Blockers in Hypertensive Patients with Diabetes and Microalbuminuria:the Study of Assessment for Kidney Function by Urinary Microalbumin in Randomized (SAKURA) Trial. (2012)
  • Author(s): Ando K, Ueshima K, Tanaka S, Kosugi S, Sato T, Matsuoka H, Nakao K, Fujita T.
  • Organizer: The 24th Meeting of the International Society of Hypertension (
  • Place of Presentation: Sydney
  • Year and Date: 20120930-1004
• [Presentation] Sympathoexcitation by oxidative stress in the brain mediates arterial pressure in metabolic syndrome. (2010)
  • Author(s): Fujita M, Ando K, Kawarazaki H, Fujita T
  • Organizer: The 23rdScientific Meeting of the International Society of Hypertension (
  • Place of Presentation: Vancouver)
  • Year and Date: 20100926-0930
• [Presentation] Mechanism of increased salt-sensitivity in young uninephrectomized Sprague-Dawley rats. (2010)
  • Author(s): Kawarazaki H, Ando K, Shibata S, Fujita M, Nagase M, Fujita T.
  • Organizer: The 23rdScientific Meeting of theInternational Society of Hypertension
  • Place of Presentation: Vancouver
  • Year and Date: 20100926-0930
• [Presentation] Meneralocorticoid receptor activation increases salt induced renal injury in young rats. (2010)
  • Author(s): Kawarazkia H, Ando K, Fujita M, Fujita T
  • Organizer: 14rdInternational Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100326-0330
• [Presentation] Sympathexcitation by oxidative stress in the brain mediates arterial pressure elevation in metabolic syndrome. (2010)
  • Author(s): Fujita M, Ando K, Kawarazaki H, Fujita T
  • Organizer: 14rdInternational Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100326-0330
• [Presentation] High fat loading accelerates salt-induced development of hypertension and renal damage in Dahl salt-sensitive rats. (2010)
  • Author(s): Ando K, Fujita M, Nagae A, Kawarazaki H, Fujita T
  • Organizer: 14rd International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100326-0330