2012 Fiscal Year Final Research Report
Role of AT4/IRAP extracted by systemic transcriptome analysis for hypertensive and diabetic renal tissue
Project/Area Number |
22590909
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | University of Fukui |
Principal Investigator |
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Research Collaborator |
SUZUKI Jinya 福井大学, 医学部, 助教 (20293417)
ARAKAWA Kenichiro 福井大学, 医学部, 助教 (80401967)
ZENIMARU Yasuo 福井大学, 医学部附属病院, 医員 (20397269)
FUJII Miki 福井大学, 医学部附属病院, 医員 (10401978)
IMAGAWA Michiko 福井大学, 医学部附属病院, 医員 (70464055)
ICHIKAWA Mai 福井大学, 医学部附属病院, 医員 (30646659)
YAMADA Mika 福井大学, 医学部附属病院, 医員 (90646655)
MAKINO Yasukazu 福井大学, 医学部, 大学院生
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Project Period (FY) |
2010 – 2012
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Keywords | レニン-アンジオテンシン系 / 網羅的発現遺伝子解析 / AT4/IRAP / 高血圧 / 糖尿病 / 腎臓 / インスリン / アミノペプチダーゼ |
Research Abstract |
We have identified AT4/IRAP as a hypertension/diabetes-specific gene through systemic transcriptome analysis followed by RT-PCR. This protein is thought to be involved in the renin-angiotensin system and insulin signal transduction. We have established a measurement system by ELISA. Thereby for the first time we could suggest the possibility that AT4/IRAP might be involved in the pathophysiology of life-style related diseases.
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[Journal Article] the Genomic Disease Outcome Consortium (G-DOC) Study Investigators, A crossover comparison of urinary albumin excretion as a new surrogate marker for cardiovascular disease among 4 types calcium channel blockers2013
Author(s)
T. Konoshita, Y. Makino, T. Kimura, M. Fujii, N. Morikawa, S. Wakahara, K. Arakawa, I. Inoki, H. Nakamura, I. Miyamori
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Journal Title
Int J Cardiol
Volume: 166
Pages: 488-452
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[Journal Article] Situs inversus and cystic kidney disease: Two adult patients with this heterogeneous syndrome2013
Author(s)
T. Onoe, T. Konoshita, K. Tsuneyama, R. Hamano, I. Mizushima, Y. Kakuchi, K. Yamada, K. Hayashi, M. Kuroda, S. Kagitani, H. Nomura, M. Yamagishi, M. Kawano
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Journal Title
Am J Case Rep
Volume: 14
Pages: 20-25
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[Journal Article] Decreased activity of daily living produced by the combination of Alzheimer's disease and lower limb fracture in elderly requiring nursing care2013
Author(s)
T. Inagawa, T. Hamagishi, Y. Takaso, Y. Hitomi, Y. Kambayashi, Y. Hibino, A. Shibata, NT. Ngoc, J. Okochi, K. Hatta, K. Takamuku, T. Konoshita, H. Nakamura
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Journal Title
Environ Health Prev Med
Volume: 18
Pages: 16-23
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[Journal Article] Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/502012
Author(s)
T. Kimura, J. Suzuki, M. Ichikawa, M. Imagawa, S. Sato, M. Fujii, Y. Zenimaru, S. Inaba, S. Takahashi, T. Konoshita, I. Miyamori
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Journal Title
Diabetes Technol Ther
Volume: 14
Pages: 545-551
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[Presentation] Systemic transcriptome analysis for extraction of specific gene clusters in diabetic nephropathy-reduced expression of insulin regulated aminopeptidase angiotensin IV receptor (IRAP/AT4) in diabetic renal tissue2010
Author(s)
T. Konoshita, Y. Takahashi, S. Mizuno, T. Kimura, M. Fujii, Y. Makino, S. Wakahara, K. Arakawa, I. Inoki, I. Miyamori
Organizer
43th Annual Meeting of American Society of Nephrology
Place of Presentation
Denver, USA
Year and Date
20101118-21
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[Presentation] The insulin regulated aminopeptidase/ angiotensin IV receptor (IRAP/AT4) gene expression is downregulated in human kidneys with diabetic nephropathy2010
Author(s)
T. Konoshita, N. Kato, Y. Takahashi, S. Mizuno, T. Kimura, M. Fujii, Y. Makino, S. Wakahara, K. Arakawa, I. Inoki, I. Miyamori
Organizer
American Diabetes Association 69th scientific sessions
Place of Presentation
Orlando, USA
Year and Date
20100625-29
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[Presentation] N/L type calcium channel blocker, cilnidipine, leads to less activation of the renin-angiotensin system compared with L type calcium channel blocker, amlodipine besilate2010
Author(s)
T. Konoshita, T. Kimura, Y. Makino, M. Fujii, S. Wakahara, K. Arakawa, I. Inoki, I. Miyamori, the Genomic Disease Outcome Consortium (G-DOC) Study Investigators
Organizer
International Society of Nephrology NEXUS Symposium
Place of Presentation
Kyoto
Year and Date
20100415-18
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[Presentation] G-DOC Study Investigators,網羅的解析による糖尿病腎症特異的発現遺伝子の抽出-Insulin Regulated Aminopeptidase (IRAP/AT4) の発現低下-2010
Author(s)
此下忠志,加藤規弘,高橋芳徳,水野真一,木村朋子,藤井美紀,牧野耕和,荒川健一郎,若原成行,居軒 功,宮森 勇
Organizer
第53回日本糖尿病学会年次学術集会
Place of Presentation
岡山
Year and Date
2010-05-29
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