2012 Fiscal Year Final Research Report
Evaluation of novel biomarkers in peritoneal fibrosis
| Project/Area Number |
22590910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kiyoshi 京都大学, 大学院・医学研究科, 准教授 (60343232)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOI Hideki 京都大学, 大学院・医学研究科, 助教 (90378779)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 腹膜透析 / 腹膜中皮細胞 / ノックアウトマウス / 腹膜炎 |
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| Research Abstract |
We used PTN knockout mice to evaluate the role of pleiotrophin (PTN) in peritoneal fibrosis, and measured the concentration of PTN in the peritoneal effluents from peritonealdialysis patients. We also measured the concentration of Ngal in peritoneal effluents.1. Role PTN in peritoneal fibrosis using PTN knockout micePTN mRNA in the peritoneum of peritoneal fibrosis mice was gradually increased. PTN knockout mice with peritoneal fibrosis model reduced inflammatory cell migration and cytokines and peritoneal permeability compared with control mice2. Measurement of PTN in peritoneal effluents and PTN mRNA in peritoneal tissues.We could detect PTN in peritoneal effluents and showed increase of PTN in effluents from patients with peritonitis. 3. Measurement of Ngal in peritoneal effluentsNgal concentration in peritoneal effluents from patients with bacterial peritonitis was 10 times higher than that from control patients. Ngal score (adjusted by internal control) was high in patients receiving PD more than 100 months.
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Research Products
(13 results)
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[Journal Article] Peritoneal fibrosis and high transport are induced in mildly pre-injured peritoneum by 3,4-dideoxyglucosone-3-ene in mice2013
Author(s)
Yokoi H, Kasahara M, Mori K, Kuwabara T, Toda N, Yamada R, Namoto S, Yamamoto T, Seki N, Souma N, Yamaguchi T, Sugawara A, Mukoyama M, Nakao K
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Journal Title
Perit Dial Int
Volume: 33:143-154
DOI
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[Journal Article] Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)2012
Author(s)
Nakao YM, Miyawaki T, Yasuno S, Nakao K, Tanaka S, Ida M, Hirata M, Kasahara M, Hosoda K, Ueshima K, Nakao K
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Journal Title
Proc Jpn Acad Ser B Phys Biol Sci
Volume: 88:454-461
URL
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[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury2012
Author(s)
Ogawa Y, Mukoyama M, Yokoi H, Kasahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
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Journal Title
J Am Soc Nephrol
Volume: 23:1198-1209
DOI
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[Journal Article] Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice2012
Author(s)
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Ogawa Y, Imamaki H, Kawanishi T, Ishii A, Koga K, Mori KP, Kato Y, Sugawara A, Nakao K
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Journal Title
Diabetologia
Volume: 55:2256-2266
DOI
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[Journal Article] Effects of renin-angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus: A systematic review and meta-analysis2012
Author(s)
Nakao YM, Teramukai S, Tanaka S, Yasuno S, Fujimoto A, Kasahara M, Ueshima K, Nakao K, Hinotsu S, Nakao K, Kawakami K
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Journal Title
Diabetes Res Clin Pract
Volume: 96(1):68-75
DOI
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[Journal Article] Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis.2012
Author(s)
Yokoi H, Kasahara M, Mori K, Ogawa Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Kato Y, Mori KP, Toda N, Ohno S, Muramatsu H, Muramatsu T, Sugawara A, Mukoyama M, Nakao K
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Journal Title
Kidney Int
Volume: 81:160-169
DOI
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[Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.Nephrol Dial Transplant2010
Author(s)
Yokoi H, Kasahara M, Mukoyama M, Mori K, Kuwahara K, Fujikura J, Arai Y, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K
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Journal Title
Nephrol Dial Transplant
Volume: 25:2120-2124
DOI
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[Presentation] Analyses of microRNAs targeting CTGF in peritoneal fibrosis mouse model2012
Author(s)
K.Koga, M.Mukoyama, H.Yokoi, M.Kasahara, K.Mori, T.Kuwabara, H.Imamaki, T.Kawanishi, A.Ishii, K.P.Mori, Y.Kato, S.Ono, N.Toda, A.Sugawara, K.Nakao
Organizer
American Society of Nephrology
Place of Presentation
San Diego, USA
Year and Date
2012-11-02
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[Presentation] Pleiotrophin causes peritoneal inflammation and mesothelial cell proliferation in a mouse model of peritoneal fibrosis2011
Author(s)
H.Yokoi, M.Kasahara, M.Mukoyama, K.Mori, Y.Ogawa, T.Kuwabara, H.Imamaki, T.kawanishi, K.Koga, A.Ishii, Y.Kato, K.P.Mori, H.Muramatsu, T.Muramatsu, A.Sugawara, K.Nakao
Organizer
World Congress of nephrology
Place of Presentation
Vancouver, Canada
Year and Date
2011-04-11
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[Presentation] The role of 3,4-dideoxyglucosone-3-ene inperitoneal fibrosis2010
Author(s)
H.Yokoi, M.Kasahara, K.Mori, T.Kuwabara, R.Yamada, S.Namoto, T.Yamamoto, N.Seki, T.Yamaguchi, N.Souma, A.Sugawara, M.Mukoyama, K.Nakao
Organizer
American Society of Nephrology
Place of Presentation
Denver, US
Year and Date
2010-11-18
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[Presentation] Atrial natriuretic peptide prevents peritoneal adhesion formation with inhibiting macrophage and CD3-positive cell infiltration2010
Author(s)
H.Yokoi, M.Kasahara, K.Mori, T.Kuwabara, T.kawanishi, K.Koga, A.Ishii, K.Mori, Y.Kato, A.Sugawara, M.Mukoyama, K.Nakao
Organizer
American Society of Nephrology
Place of Presentation
Denver, USA
Year and Date
2010-11-18
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