2012 Fiscal Year Final Research Report
Roles of interleukin-18 and osteopontin in renal fibrosis
Project/Area Number |
22590912
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | Ehime University |
Principal Investigator |
OKURA Takafumi 愛媛大学, 大学院・医学系研究科, 准教授 (40260385)
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Co-Investigator(Renkei-kenkyūsha) |
MIYOSHI Ken-ichi 愛媛大学, 大学院・医学系研究科, 助教 (50423439)
IRITA Jun 愛媛大学, 医学部附属病院, 助教 (00423442)
JHOTOKU Masanori 愛媛大学, 医学部附属病院, 医員 (10452690)
NAGAO Tomoaki 愛媛大学, 医学部附属病院, 医員 (20512164)
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Project Period (FY) |
2010 – 2012
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Keywords | Interleukin-18 / オステオポンチン / アルドステロン / 腎線維化 / 高血圧 |
Research Abstract |
We evaluated the effects of IL-18 which is a pro-inflammatory cytokine on kidney injury by aldosterone. Wild type or IL-18 knock out (KO) mouse were unilateral nephrectomized and treated with high salt and aldosterone. In wild type mouse, glomerular hypertrophy, mesangial matrix expansion and interstitial fibrosis were observed. On the other hand, in IL-18 KO mouse, these changes were diminished. In wild type mouse, osteopontin (OPN) was up-regulated but not in KO mouse. These results suggested that aldosterone induced renal fibrosis by induction of IL-18 and OPN.
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Research Products
(4 results)
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[Journal Article] Osteopontin Plays a Critical Role in Interstitial Fibrosis but Not Glomerular Sclerosis in Diabetic Nephropathy2012
Author(s)
NagaoT, Okura T, Irita J, Jotoku M, Enomoto D, Desilva VR, Miyoshi K, Kurata M, Matsui Y, Uede T, Higaki J
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Journal Title
Nephron Extra
Volume: 2
Pages: 87-103
DOI
Peer Reviewed
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[Journal Article] Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney.2011
Author(s)
Irita J, Okura T, Jotoku M, NagaoT, Enomoto D, Kurata M, Desilva VR, Miyoshi K, Matsui Y, Uede T, Denhardt DT, Rittiling SR, Higaki J.
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Journal Title
American Journal of Physiology renal physiology
Volume: 301
Pages: E833-844
DOI
Peer Reviewed
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